Two instances of leukaemia occurring in siblings among 31 cases in a 3-year period study in a densely populated medium-sized town and surrounding areas with an approximate population 200,000 are reported. The incidence of familial leukaemia is unusually high (6% although the general incidence remains approximately the same when compared with regional and national figures. Multiple cases of leukaemia and cancer among the members of the families in this report are thought to be influenced by hereditary factors. Chromosome analysis in two siblings revealed poly-ploid abnormality in 95% of bone marrow cells in one case.

Keywords:
Familial leukaemia, Heredity in leukaemia, Leukaemia and cancer
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© 1972 S. Karger AG, Basel
1972
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