Actinomycin binding, which is considered as an expression of genetic activity, has been evaluated in acute and chronic cells and compared with values for both normal cells ad pathologically (infectious mononucleosis) Lymphatic leukaemia or PHA-stimulated lymphocytes, A significant increase in binding accompanies lymphocyte activation. In acute leukaemia, the binding values were well above those observed in normal cells, and differences were noted between the proliferating and non-proliferating blasts. In chronic lymphatic leukaemia, on the other hand, actinomycin binding is considerably decreased. This is taken as a sign of marked changes in genetic regulation.

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