A case of von Willebrand’s disease with marked platelet defects is reported. In comparison with normal control subjects, the patient’s platelets have presented low ADP and AMP levels. Six hours after a normal human plasma transfusion, a transitory correction of platelet aggregation by ADP 10-4M and a strong rise of all platelet nucleotides have been ovserved, in addition to the increase of AHF activity and the partial normalization of the prolonged bleeding time. These data support the hypothesis that the temporary correction of the ADP-dependent aggregation has been due to an active synthesis of platelet nucleotides under the influence of one or more unknown factors contained in the transfused plasma.

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