The leukemic lymphocyte has a limited ability to appropriately raise its metabolism under selected stimuli (phytohemagglutinin [PHA] and methylene blue [MB]); a correlative and interdependant relationship exists between glucose utilization and polynucleotide formation.The results of these studies suggest that the lymphocyte in chronic lymphocytic leukemia reacts immunologically in accord with limitations imposed upon it by inherent cellular deficiencies. These restrictions may prevent in vivo maximal immunogenic response and effective participation in host defense.
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© 1972 S. Karger AG, Basel
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