In 3 patients with dysproteinaemia the defects in haemostasis were investigated: Waldenström’s macroglobulinaemia, macroglobulinaemia associated with undifferentiated malignancy in the marrow, diffuse hypergammaglobulinaemia associated with drug sensitive purpura. Platelet factor 3 release, reduction of its total contents and poor platelet adhesion were found in all 3 patients. Platelet aggregation was absent in 2 patients who had macroglobulinaemia with monoclonal spike. It is suggested that the platelet factor 3 assay may be of value in the investigation of these changes in relation to dysproteinaemias.
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© 1972 S. Karger AG, Basel
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