The continuous administration of tridated thymidine (3H-TdR) into pregnant rats resulted in a complete labelling of cell nuclei in the offspring. Further injections with 3H-TdR for 6 weeks maintained the 100-percent labelling. Six weeks after the last 3H-TdR application, only cytokinetically resting cells were selectively labelled in the bone marrow of these animals. These comprised reticular cells, endothelial cells and 5% of the bone marrow lymphocyte population. In these animals a standardised amount of the marrow of both the femora was removed by mechanical means. In the undepleted part of the femur a stimulation of formerly cytokinetically resting cells could be observed. There was no indication of stimulation in distant bone marrow parts. In an additional experiment in which a single injection of 3H-TdR was given at various intervals after depletion, the above findings were supported by a high uptake of 3H-TdR in the stroma cells of the bone marrow. The findings indicate that repopulation of bone marrow stroma cells is a necessary process for a restoration of haemopoiesis.

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