The sequence of changes in the CFU content of murine bone marrow has been studied during the brief units period of survival which follows the i.v. administration of a single lethal dose (100 μg) of mustine hydrochloride. Within 24 h a tenfold decrease in the number of CFU which can be aspirated from a single femoral diaphysis has been observed. This is followed by an increase which restores the CFU content of the femoral diaphysis to control values between the 4th and the 8th days after treatment.

Keywords:
Colony forming, Mouse bone marrow, Nitrogen mustard
© 1971 S. Karger AG, Basel
1971
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