After one or two days, blood loss causes thrombocytosis and in the serum of exsanguined experi- mental animals a thrombocytosis-producing factor ap- pears. Splenectomy, adrenalectomy and hypophysectomy do not suspend the appearance of the serum factor. After exsanguination following nephrectomy by 2–18 h, the serum factor inducing thrombocytosis does not appear, whereas animals with ureter ligation react like those not operated upon. During the phase of isolated thrombocytopenia produced by intravenous administration of thromboplastin, the serum of nephrectomized animals shows a thrombocytosis-producing activity.

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