Two patients with a known quinine induced allergic thrombocytopenia have been studied in order to detect in vitro the presence of drug-dependent antibodies in their plasma. The platelet factor 3 and platelet acid phosphatase availability tests have shown that these antibodies are still present several years after the last exposition to quinine followed by the typical clinical symptoms. The demasking of acid phosphatase activity is increased in presence of calcium ions. The possible mechanisms leading to the demasking of PF 3 and acid phosphatase after exposition of the patient’s platelets to quinine are discussed

Keywords:
Acid phosphatase of platelets, Platelet antibodies, Platelet factor 3, Quinine hypersensitivity, Thrombocytopenia
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© 1971 S. Karger AG, Basel
1971
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