Abstract
The PHA-induced blastogenesis in lymphocyte cultures of acute leukemia patients in remission was investtigated. Lymphocytes of patients untreated for more than 2 weeks showed normal blast transformation. Lymphocytes of patients in treatment with 6-mercaptopurine or methotrexate showed in some cases normal blast transformation and in other cases lack of blastogenesis. It seems that in these patients the lymphocytes are sensible to the iramunodepressive action of the mentioned antimetabolites, whereas in the other patientsthe lymphocytes are resistant to that action
© 1971 S. Karger AG, Basel
1971
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