Subcutaneous inoculation of leukemic cell suspensions of 10-2 to 10-6.concentration into 84 ‘strain 2’andF1 hybrid guinea pigs produced subcutaneous leukemic infiltrations at the site of inoculation in 80 of the inoculated animals leading to a generalized stem-cell leukemiabWhen 96 ‘strain 2’ and F1hybrid guinea pigs were inoculated intradermally, 67 of them developed intradermal tumors; 34 of these tumors (51%) regressed spontaneously. Twenty-one females and 11 males in which the intradermal tumors regressed, were reinoculated subcutaneously. Nineteen out of 21 females (90%) and 7 out of 11 males (64%) resisted the challenging inoculation, suggesting thereby that the induced immunity was more pronounced in females, than in males. The acquired immunity could not be transmitted to other guinea pigs by a serum collected from the immunized animals

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