Lymphoid myelofibrosis represents an anatomoclinical syndrome of constant symptomatology characterized predominantly by splenomegaly, few lymphadenopathies, pancytopenia with blood lymphocytosis, and a hypoplastic myelogram comprising lymphocytes and histiocytes. Histological study of bone marrow biopsy shows association of lymphoid proliferation as well as network cell proliferation, giving rise to a dense lattice of reticulum and collagen fibers, without osteosclerosis. The cytology of the syndrome and its relationship to lymphoid leukemia, Waldenström’s disease and those syndromes termed reticuloendotheliosis or malignant histiocytosis is discussed. It is not easy to evaluate the efficiency of therapeutic measures, since myelofibrosis precludes that kind of chemotherapy as is currently used in lymphoproliferative syndromes; therefore, prognosis is incertain although clinical evolution is slow

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