Testicular lymphoma is a rare condition, so large scale prospective studies are difficult to conduct. Consensus regarding standard treatment is lacking. This study retrospectively reviewed 22 patients with testicular lymphoma. One patient with diffuse large B-cell lymphoma (DLBCL) was lost to follow-up after diagnosis. Two patients with Burkitt's lymphoma had poor outcomes regardless of treatment. Thus, we analyzed the clinical features, treatments, and outcomes of 19 patients with DLBCL. The median progression-free and overall survival was 28.3 and 36.3 months, respectively. A good response to treatment was a favorable prognostic factor. Because of the high relapse rate, the outcome is poor for testicular lymphoma. Therefore, long-term follow-up is strongly recommended.

Koukourakis G, Kouloulias V: Lymphoma of the testis as primary location: tumour review. Clin Transl Oncol 2010;12:321-325.
Verma N, Lazarchick J, Gudena V, Turner J, Chaudhary UB: Testicular lymphoma: an update for clinicians. Am J Med Sci 2008;336:336-341.
Vitolo U, Ferreri AJ, Zucca E: Primary testicular lymphoma. Crit Rev Oncol Hematol 2008;65:183-189.
Shahab N, Doll DC: Testicular lymphoma. Semin Oncol 1999;26:259-269.
Zouhair A, Herrmann E, Ugurluer G, Gaye PM, Mirimanoff RO, Ozsahin M: Primary testicular lymphoma. Swiss Med Wkly 2010;140:w13076.
Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M: Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res 1971;31:1860-1861.
A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med 1993;329:987-994.
Cheson BD, Pfistner B, Juweid ME, Gascoyne RD, Specht L, Horning SJ, Coiffier B, Fisher RI, Hagenbeek A, Zucca E, Rosen ST, Stroobants S, Lister TA, Hoppe RT, Dreyling M, Tobinai K, Vose JM, Connors JM, Federico M, Diehl V, International Harmonization Project on Lymphoma: Revised response criteria for malignant lymphoma. J Clin Oncol 2007;25:579-586.
Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM, Lister TA, Vose J, Grillo-Lopez A, Hagenbeek A, Cabanillas F, Klippensten D, Hiddemann W, Castellino R, Harris NL, Armitage JO, Carter W, Hoppe R, Canellos GP: Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. J Clin Oncol 1999;17:1244.
Kaplan EL, Meier P: Non-parametric estimation for incomplete observations. J Am Stat Assoc 1958;53:457-481.
Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-170.
Pectasides D, Economopoulos T, Kouvatseas G, Antoniou A, Zoumbos Z, Aravantinos G, Tsatalas C, Halikia A, Nikolaides C, Kiamouris C, Pappa E, Pavlidis N, Skarlos D, Fountzilas G, Dimopoulos MA: Anthracycline-based chemotherapy of primary non-Hodgkin's lymphoma of the testis: the Hellenic Cooperative Oncology Group experience. Oncology 2000;58:286-292.
Vural F, Cagirgan S, Saydam G, Hekimgil M, Soyer NA, Tombuloglu M: Primary testicular lymphoma. J Natl Med Assoc 2007;99:1277-1282.
Connors JM, Klimo P, Voss N, Fairey RN, Jackson S: Testicular lymphoma: improved outcome with early brief chemotherapy. J Clin Oncol 1988;6:776-781.
Gundrum JD, Mathiason MA, Moore DB, Go RS: Primary testicular diffuse large B-cell lymphoma: a population-based study on the incidence, natural history, and survival comparison with primary nodal counterpart before and after the introduction of rituximab. J Clin Oncol 2009;27:5227-5232.
Linassier C, Desablens B, Lefrancq T, Le Prise PY, Harousseau JL, Jacob C, Gandhour C, Haillot O, Lucas V, Leloup R, Escoffre M, Colombat P, Tabuteau S, GOELAMS Study Group: Stage I-IIE primary non-Hodgkin's lymphoma of the testis: results of a prospective trial by the GOELAMS Study Group. Clin Lymphoma 2002;3:167-172.
Tondini C, Ferreri AJ, Siracusano L, Valagussa P, Giardini R, Rampinelli I, Bonadonna G: Diffuse large-cell lymphoma of the testis. J Clin Oncol 1999;17:2854-2858.
Duncan PR, Checa F, Gowing NF, McElwain TJ, Peckham MJ: Extranodal non-Hodgkin's lymphoma presenting in the testicle: a clinical and pathologic study of 24 cases. Cancer 1980;45:1578-1584.
Tepperman BS, Gospodarowicz MK, Bush RS, Brown TC: Non-Hodgkin lymphoma of the testis. Radiology 1982;142:203-208.
Visco C, Medeiros LJ, Mesina OM, Rodriguez MA, Hagemeister FB, McLaughlin P, Romaguera JE, Cabanillas F, Sarris AH: Non-Hodgkin's lymphoma affecting the testis: is it curable with doxorubicin-based therapy? Clin Lymphoma 2001;2:40-46.
Buskirk SJ, Evans RG, Banks PM, O'Connell MJ, Earle JD: Primary lymphoma of the testis. Int J Radiat Oncol Biol Phys 1982;8:1699-1703.
Moller MB, d'Amore F, Christensen BE: Testicular lymphoma: a population-based study of incidence, clinicopathological correlations and prognosis. The Danish Lymphoma Study Group, LYFO. Eur J Cancer 1994;30A:1760-1764.
Zietman AL, Coen JJ, Ferry JA, Scully RE, Kaufman DS, McGovern FG: The management and outcome of stage IAE nonHodgkin's lymphoma of the testis. J Urol 1996;155:943-946.
Doll DC, Weiss RB: Malignant lymphoma of the testis. Am J Med 1986;81:515-524.
Read G: Lymphomas of the testis - results of treatment 1960-77. Clin Radiol 1981;32:687-692.
Crellin AM, Hudson BV, Bennett MH, Harland S, Hudson GV: Non-Hodgkin's lymphoma of the testis. Radiother Oncol 1993;27:99-106.
Lagrange JL, Ramaioli A, Theodore CH, Terrier-Lacombe MJ, Beckendorf V, Biron P, Chevreau CH, Chinet-Charrot P, Dumont J, Delobel-Deroide A, D'Anjou J, Chassagne C, Parache RM, Karsenty JM, Mercier J, Droz JP: Radiation Therapy GROUP, Genito-Urinary Group of the French Federation of Cancer Centres: Non-Hodgkin's lymphoma of the testis: a retrospective study of 84 patients treated in the French anticancer centres. Ann Oncol 2001;12:1313-1319.
Martenson JA Jr, Buskirk SJ, Ilstrup DM, Banks PM, Evans RG, Colgan JP, Earle JD: Patterns of failure in primary testicular non-Hodgkin's lymphoma. J Clin Oncol 1988;6:297-302.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E: First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial. J Clin Oncol 2011;29:2766-2772.
Zouhair A, Weber D, Belkacemi Y, Ketterer N, Dietrich PY, Villa S, Scandolaro L, Bieri S, Studer G, Delacretaz F, Girardet C, Mirimanoff RO, Ozsahin M, Rare Cancer Network: Outcome and patterns of failure in testicular lymphoma: a multicenter Rare Cancer Network study. Int J Radiat Oncol Biol Phys 2002;52:652-656.
Park BB, Kim JG, Sohn SK, Kang HJ, Lee SS, Eom HS, Kwon HC, Oh SY, Kang JH, Oh SJ, Shin HJ, Suh C, Kim JH, Kim HY, Kim K, Ryoo BY, Kim WS: Consideration of aggressive therapeutic strategies for primary testicular lymphoma. Am J Hematol 2007;82:840-845.
Fonseca R, Habermann TM, Colgan JP, O'Neill BP, White WL, Witzig TE, Egan KS, Martenson JA, Burgart LJ, Inwards DJ: Testicular lymphoma is associated with a high incidence of extranodal recurrence. Cancer 2000;88:154-161.
Thomas LC, Adonizio C, Filicko-O'Hara J, Golshayan AR, Costa LJ, Morris GJ: Testicular lymphoma. Semin Oncol 2010;37:549-554.
Touroutoglou N, Dimopoulos MA, Younes A, Hess M, Pugh W, Cox J, Cabanillas F, Sarris AH: Testicular lymphoma: late relapses and poor outcome despite doxorubicin-based therapy. J Clin Oncol 1995;13:1361-1367.
Hasselblom S, Ridell B, Wedel H, Norrby K, Sender Baum M, Ekman T: Testicular lymphoma - a retrospective, population-based, clinical and immunohistochemical study. Acta Oncol 2004;43:758-765.
Zucca E, Conconi A, Mughal TI, Sarris AH, Seymour JF, Vitolo U, Klasa R, Ozsahin M, Mead GM, Gianni MA, Cortelazzo S, Ferreri AJ, Ambrosetti A, Martelli M, Thieblemont C, Moreno HG, Pinotti G, Martinelli G, Mozzana R, Grisanti S, Provencio M, Balzarotti M, Laveder F, Oltean G, Callea V, Roy P, Cavalli F, Gospodarowicz MK, International Extranodal Lymphoma Study Group: Patterns of outcome and prognostic factors in primary large-cell lymphoma of the testis in a survey by the International Extranodal Lymphoma Study Group. J Clin Oncol 2003;21:20-27.
Batchelor T, Leahy N, Kaufman D: High-dose methotrexate for isolated central nervous system relapse in patients with testicular non-Hodgkin's lymphoma. Clin Lymphoma 2001;2:116-119.
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