Background: Primary bone lymphoma is a rare disease, representing less than 5% of all extra-nodal non-Hodgkin lymphomas. Materials and Methods: We retrospectively searched the database of the lymphoma unit, Hematology/Lymphoma Department, Athens General Hospital ‘Evangelismos' for primary bone lymphoma patients. Demographic and clinicopathologic data were collected and overall survival was analyzed. A log-rank test was used in a univariate analysis to identify factors affecting overall survival. Results: We identified 24 and analyzed data from 22 patients. 12 were male (54.5%) and 10 female (45.4%) and their median age was 55 years (range: 19-83). Most patients had localized disease at the time of diagnosis (n = 19, 86.3%), the most common site was the spine (n = 11, 50%) and the most common histology was diffuse large B-cell lymphoma. 21 patients received chemotherapy as initial therapy and 16 received combined chemoradiation. 81.8% of the patients (n = 18) achieved complete remission. 5-year survival rate was 86.3% and overall survival was found to be affected by the patients' initial response to treatment. Conclusions: Primary bone lymphoma is usually associated with a good prognosis. Prospective studies are needed in order to clarify the effect of immunochemotherapy in overall survival.

Parker F, Jackson H: Primary reticulum cell sarcoma of bone. Surg Gynecol Obstet 1939;68:45-53.
Fidias P, Spiro I, Sobczak ML, Nielsen GP, Ruffolo EF, Mankin H, Suit HD, Harmon DC: Long-term results of combined modality therapy in primary bone lymphomas. Int J Radiat Oncol Biol Phys 1999;45:1213-1218.
Beal K, Allen L, Yahalom J: Primary bone lymphoma: treatment results and prognostic factors with long-term follow-up of 82 patients. Cancer 2006;106:2652-2656.
Limb D, Dreghorn C, Murphy JK, Mannion R: Primary lymphoma of bone. Int Orthop 1994;18:180-183.
Dubey P, Ha CS, Besa PC, Fuller L, Cabanillas F, Murray J, Hess MA, Cox JD: Localized primary malignant lymphoma of bone. Int J Radiat Oncol Biol Phys 1997;37:1087-1093.
Freeman C, Berg JW, Cutler SJ: Occurrence and prognosis of extranodal lymphomas. Cancer 1972;29:252.
Jawad MU, Schneiderbauer MM, Min ES, Cheung MC, Koniaris LG, Scully SP: Primary Lymphoma of Bone in Adult Patients. Cancer 2010;116:871-879.
Swerdlow SH, Steven H: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (ed 4th). Lyon, France: IARC Press; 2008.
Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM, Lister TA, Vose J, Grillo-López A, Hagenbeek A, Cabanillas F, Klippensten D, Hiddemann W, Castellino R, Harris NL, Armitage JO, Carter W, Hoppe R, Canellos GP: Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. J Clin Oncol 1999;17:1244.
Mikhaeel NG: Primary Bone Lymphoma. Clin Oncol 2012;24:366-370.
Wang J, Kim D, Goldberg M: Anaplastic Large Cell Ki-1 Lymphoma: Primary Bone Presentation in an Elderly Man. Acta Haematol 1996;96:45-49.
Tanimura A, Adachi Y, Tanda M, Yuasa H, Ishii Y, Katou Y: Primary Peripheral B Cell Lymphoma, Burkitt-Like, of the Cranial Vault. Acta Haematol 2005;113:258-261.
Maruyama D, Watanabe T, Beppu Y, Kobayashi Y, Kim SW, Tanimoto K, Makimoto A, Kagami Y, Terauchi T, Matsuno Y, Tobinai K: Primary Bone Lymphoma: A New and Detailed Characterization of 28 Patients in a Single-Institution Study. Jpn J Clin Oncol 2007;37:216-223.
Ueda T, Aozasa K, Ohsawa M, Yoshikawa H, Uchida A, Ono K, Matsumoto K: Malignant lymphomas of bone in Japan. Cancer 1989;64:2387-2392.
Heyning FH, Hogendoorn PC, Kramer MH, Hermans J, Kluin-Nelemans JC, Noordijk EM, Kluin PM: Primary non-Hodgkin's lymphoma of bone: a clinicopathological investigation of 60 cases. Leukemia 1999;13:2094-2098.
Zinzani PL, Carrillo G, Ascani S, Barbieri E, Tani M, Paulli M, Stefoni V, Sabattini E, Alinari L, Binazzi R, Tura S, Baccarani M, Pileri SA: Primary Bone Lymphoma: experience with 52 patients. Haematologica 2003;88:280-285.
Ramadan KM, Shenkier T, Sehn LH, Gascoyne RD, Connors JM: A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann of Oncol 2007;18:129-135.
Dosoretz DE, Murphy GF, Raymond AK, Doppke KP, Schiller AL, Wang CC, Suit HD: Radiation therapy for primary lymphoma of bone. Cancer 1983;51:44-46.
Stein ME, Kuten A, Gez E, Rosenblatt KE, Drumea K, Ben-Shachar M, Zidan J, Haim N, Epelbaum R: Primary lymphoma of bone - a retrospective study. Oncology 2003;64:322-327.
Lewis VO, Primus G, Anastasi J, Doherty D, Montag AG, Peabody TD, Simon MA: Oncologic outcomes of primary lymphoma of bone in adults. Clin Orthop Relat Res 2003;415:90-97.
de Leval L, Braaten KM, Ancukiewicz M, Kiggundu E, Delaney T, Mankin HJ, Harris NL: Diffuse large B-cell lymphoma of bone. An analysis of differentiation-associated antigens with clinical correlation. Am J Surg Pathol 2003;27:1269-1277.
Barbieri E, Cammelli S, Mauro F, Perini F, Cazzola A, Neri S, Bunkheila F, Ferrari S, Brandoli V, Zinzani P, Mercuri M, Bacci G: Primary non-Hodgkin's lymphoma of the bone: treatment and analysis of prognostic factors for stage I and stage II. Int J Radiat Oncol Biol Phys 2004;59:760-764.
Horsman JM, Thomas J, Hough R, Hancock BW: Primary bone lymphoma: a retrospective analysis. Int J Oncol 2006;28:1571-1575.
Alencar A, Pitcher D, Byrne G, Lossos IS: Primary bone lymphoma - the University of Miami experience. Leuk Lymphoma 2010;51:39-49.
Pellegrini C, Gandolfi L, Quirini F, Ruggieri P, Stefoni V, Derenzini E, Broccoli A, Argnani L, Pileri S, Mercuri M, Baccarani M, Zinzani PL: Primary bone lymphoma: evaluation of chemoimmunotherapy as front-line treatment in 21 patients. Clin Lymphoma Myeloma Leuk 2011;11:321-325.
Nasiri MR, Varshoee F, Mohtashami S, Raziee HR, Aledavood A, Ghafarzadeh K, Memar B, Vojdani S, Sarvizadeh M: Primary bone lymphoma: a clinicopathological retrospective study of 28 patients in a single institution. J Res Med Sci 2011;16:814-820.
Cai L, Stauder MC, Zhang YJ, Poortmans P, Li YX, Constantinou N, Thariat J, Kadish SP, Nguyen TD, Kirova YM, Ghadjar P, Weber DC, Bertran VT, Ozsahin M, Mirimanoff RO: Early-stage primary bone lymphoma: a retrospective, multicenter Rare Cancer Network (RCN) Study. Int J Radiat Oncol Biol Phys 2012;83:284-291.
Kim SY, Shin DY, Lee SS, Suh C, Kwak JY, Kim HG, Lee JH, Lee SI, Lee YR, Kang SH, Mun SK, Lee MJ, Lee HR, Yang SH, Kang HJ: Clinical characteristics and outcomes of primary bone lymphoma in Korea. Korean J Hematol 2012;47:213-218.
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