We present 2 patients with hyperferritinemia, increased liver iron and hemochromatosis-associated HFE genotypes. At diagnosis, both patients had chronic anemia that prevented initiation of phlebotomy. Iron chelation with deferasirox proved to be a safe and effective means of substantially lowering ferritin levels.

Pietrangelo A: Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology 2010;139:393–408, 408e 391–392.
Adams PC, Barton JC: How I treat hemochromatosis. Blood 2010;116:317–325.
Meerpohl JJ, Antes G, Rucker G, Fleeman N, Niemeyer C, Bassler D: Deferasirox for managing transfusional iron overload in people with sickle cell disease. Cochrane Database Syst Rev 2010:CD007477.
Wood JC, Kang BP, Thompson A, Giardina P, Harmatz P, Glynos T, Paley C, Coates TD: The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores. Blood 2010;116:537–543.
Portmann BC, Thompson RJ, Roberts EA, Paterson AC: Genetic and metabolic liver disease; in Burt AD, Portmann BC, Ferrell LD (eds): MacSweens’s Pathology of the Liver. London, Elsevier, 2005, vol 5, pp 199–326.
Wick M, Pinggera G, Lehmann P: Clinical Aspects and Laboratory. Iron Metabolism, Anemias: Novel Concepts in the Anemias of Malignancies and Renal and Rheumatoid Diseases. Wien, Springer, 2009.
Phatak P, Brissot P, Wurster M, Adams PC, Bonkovsky HL, Gross J, Malfertheiner P, McLaren GD, Niederau C, Piperno A, Powell LW, Russo MW, Stoelzel U, Stremmel W, Griffel L, Lynch N, Zhang Y, Pietrangelo A: A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis. Hepatology 2010;52:1671–1779.
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