We have previously found that a major histocompatibility complex (MHC) restriction exists between pluripotent hemopoietic stem cells (P-HSCs) and stromal cells. Based on this finding, we have recently found using chimerism-resistant mouse combinations that successful allogeneic (allo) BMT can be executed by recruiting donor bone marrow stromal cells. The strategies include donor bone grafts under the skin, injection of whole bone marrow cells (BMCs) including stromal cells via the portal vein (PV), and injection of whole BMCs directly into the bone marrow cavity (intra-bone marrow [IBM] injection). In this paper, we show how stromal cells play crucial roles in overcoming chimerism-resistant allo BMT.

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