The type III tyrosine kinase receptor c-KIT and its ligand stem cell factor (SCF; also known as KIT ligand, mast cell growth factor and steel factor) are closely involved in the regulation of a wide range of tissues at different stages of life. This review provides an outline of the discovery, structure and expression of SCF and c-KIT but concentrates on their respective roles in the regulation of human haemopoiesis and how this knowledge might be exploited in the clinical setting.

Keywords:
Stem cell factor, Haemopoiesis, Ex vivo, Expansion, PBSC mobilisation, Aplastic anaemia
© 2001 S. Karger AG, Basel
2001
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