Eighteen patients with acute leukemia were studied to evaluate their left ventricular systolic and diastolic function by M mode, two-dimensional and Doppler echocardiographic techniques. The study group was compared with another group of 18 patients of similar age with iron deficiency anemia. The latter group had a comparable heart rate and levels of Hb. There were no differences in systolic function, whereas the diastolic function was lower in patients with acute leukemia (E/A ratio = 1.1 ± 0.3 vs. 1.42 ± 0.5, p < 0.05). It is concluded that left ventricular diastolic dysfunction is more common in patients with acute leukemia and may be an indicator of restrictive cardiomyopathy.

Chia BL, Da Costa JL, Ransome GA: Cardiac tamponade due to leukemic pericardial effusion. Thorax 1973;28:657–659.
Athens J, Ward J: Complications of hematopoietic neoplasm; in Lee GR (ed): Wintrobe’s Clinical Hematology. Philadelphia, Lea & Febiger, 1993, vol 2, pp 1792–1842.
Dresdale DT: Heart block and leukemic cell infiltration of the interventricular septum of the heart. Am J Med 1949;6:530–532.
Orts M, Ribera JM, Calatrava A, Larrouse E, Catalan R, Navarro JT, Milla F, Feliu E: Pseudotumorous cardiac infiltration in a patient with acute monoblastic leukemia. Med Clin 1996;106:545–547.
Anderson B, Moberg A: Unexpected death due to leukemic infiltrations of the heart. Opuscula Med 1958;3:315–316.
Kuecherer HF, Kee LL, Modin G, Cheitlin MD, Schiller NB: Echocardiography in serial evaluation of left ventricular systolic and diastolic function: Importance of image acquisition, quantitation and physiologic variability in clinical and investigational applications. J Am Soc Echocardiogr 1991;4:203–214.
Applegate R, Little WC: Systolic and diastolic left ventricular function; in Zipes D (ed): Progress in Cardiology. Philadelphia, Lea & Febiger, 1991, vol 4/2, pp 63–77.
Borow KM, Propper R, Biorman FZ: Left ventricular end-systolic pressure dimension relation in patients with thalassemia major: A new noninvasive method for assessing contractile state. Circulation 1992;66:980–985.
Takahashi M, Kurokawa S, Tsuyusaki T, Kikawada R: Studies of hyperkinetic circulatory state in chronic anemia. J Cardiol 1990;20:331–339.
Bahl VK, Malhotra DP, Kumar D, Agarwal R, Goswami KC, Bajaj R, Shrivastava S: Noninvasive assessment of systolic and diastolic left ventricular function in patients with severe anemia: A combined M-mode, two dimensional and Doppler echocardiographic study. Am Heart J 1992;124:1516–1523.
Sahn DJ, De Mario A, Kirsk J, Weyman A: The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurement. Circulation 1978;58:1072–1083.
Labowitz AJ, Pearson AC: Evaluation of left ventricular diastolic function: Clinical relevance and recent Doppler echocardiography insights. Am Heart J 1987;114:836–851.
Appleton CA, Hatle LK, Popp RL: Relations of transmitral flow velocity patterns to left ventricular diastolic function: New insights from a combined hemodinamic and Doppler echocardiographic study. J Am Coll Cardiol 1988;12:426–440.
Spirito P, Maron MJ, Bonow RO: Noninvasive assessment of left ventricular diastolic function: Comparative analysis of Doppler echocardiographic and radionuclide angiographic techniques. J Am Coll Cardiol 1986;7:518–526.
Wilson N, Goldberg SJ, Dickinson DF, Scott D: Normal intracardiac and great artery blood velocity measurements by pulsed Doppler echocardiography. Br Heart J 1985;53:451–458.
Spirito P, Maron BJ: Influence of aging on Doppler echocardiographic indices of left ventricular diastolic function. Br Heart J 1988;59:672–679.
Bryg RJ, Williams GA, Labowitz A: Effects of aging on left ventricular diastolic filling in normal subjects. Am J Cardiol 1987;59:971–974.
Voutilainen S, Kupari M, Hippelainen K, Ventila M, Heikkila J: Factors influencing Doppler indexes of left ventricular filling in healthy persons. Am J Cardiol 1991;68:653–659.
Bahl VK, Dave TH, Sundaram KR, Shrivastava S: Pulsed Doppler echocardiographic indices of left ventricular function in normal subject. Clin Cardiol 1992;15:504–512.
Silberbauer K, Juhasz M, Ohrenberger G, Hess C: Noninvasive assessment of left ventricular diastolic function by pulsed Doppler echocardiography in young alcoholics. Cardiology 1988;75:431–439.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.