Two patients with chronic myelogenous leukemia are described in whom thrombotic thrombocytopenic purpura (TTP) developed following treatment by interferon-α. In one of the patients, a lymphoblastic transformation was diagnosed concomitantly. Prompt institution of plasmapheresis, steroids and vincristine resulted in complete resolution. In the hitherto reported case of TTP complicating interferon-α treated chronic myelogenous leukemia, the course was fatal.

1.
Gordon LI, Kwaan HC: Cancer- and drug-associated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Semin Hematol 1997;34:140–147.
2.
Bennet CI, Weinberg PD, Rozenberg-Ben-Dror K, Yarnold PR, Kwaan MC, Green D: Thrombotic thrombocytopenic purpura associated with ticlopidine. Ann Intern Med 1998;128:541–544.
3.
Rose M, Rowe JM, Eldor A: The changing course of thrombotic thrombocytopenic purpura. Blood Rev 1993;7:94–103.
4.
Shammas F, Meyer P, Heikkila R, Apeland T, Goransson L, Berland J, Kjellevold K: Thrombotic microangiopathy in a patient with chronic myelogenous leukemia on hydroxyurea. Acta Haematol 1997;97:184–186.
5.
Stratta P, Canavese C, Dogliani M, Thea A, Degani G, Mairone L, Vercellone A: Hemolytic-uremic syndrome during recombinant alpha-interferon treatment for hairy cell leukemia. Ren Fail 1993;15:559–561.
6.
Harvey M, Rosenfeld D, Davies D, Hall BM: Recombinant interferon alpha and hemolytic uremic syndrome: cause or coincidence? Am J Hematol 1994;46:152–153.
7.
Schlaifer D, Dumazer P, Spenatto N, Mignon-Conte M, Brousset P, Lumbroso C, Cooper M, Muller C, Huguet F, Attal M, Laurent G, Pris J: Hemolytic-uremic syndrome in a patient with chronic myelogenous leukemia treated with interferon alpha. Am J Hematol 1994;47:254–255.
8.
Honda K, Ando A, Endo M, Shimizu K, Higashihara M, Nitta K, Nihei H: Thrombotic microangiopathy associated with alpha-interferon therapy for chronic myelocytic leukemia. Am J Kidney Dis 1997;30:123–130.
9.
Ubara Y, Hara S, Takedatu H, Katori H, Yamada K, Yoshihara K, Matsushita Y, Yokoyama K, Takemoto F, Yamada A, Takagawa R, Endo Y, Hara M, Koida I, Kumada H: Hemolytic uremic syndrome associated with beta-interferon therapy for chronic hepatitis C. Nephron 1998;80:107–108.
10.
Aguiar RCT, Beitler B, Dorihiac-Llacer PE, Chamone DAF: Secondary chronic myelogenous leukemia: A diverse pathogenesis. Acta Haematol 1994;92:101–103.
11.
Moses J, Lichtman SM, Brody J, Wisch N, Moake J: Hairy cell leukemia in association with thrombotic thrombocytopenic purpura and factor VIII antibodies. Leuk Lymphoma 1996;22:351–354.
12.
Moake JL: Studies on the pathophysiology of thrombotic thrombocytopenic purpura. Semin Hematol 1997;34:83–89.
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