...Tzy Harn Chua; Khoon Leong Chuah Introduction: There is increasing need for more testing in non-small cell lung cancer given the introduction of newer targeted therapies. Cytological specimens including conventional smears (CS), cell blocks (CB), and liquid-based cytology (LBC) are an alternative...

...Eduardo Clery; Pasquale Pisapia; Elena Vigliar; Umberto Malapelle; Claudio Bellevicine; Giancarlo Troncone; Fernando C. Schmitt In the late stages of non-small cell lung cancer, the detection of sensitizing mutations of the epidermal growth factor receptor ( EGFR ) is mandatory to select patients...

...Pasquale Pisapia; Umberto Malapelle; Giancarlo Troncone The identification of non-small cell lung cancer (NSCLC) patients potentially responsive to targeted therapies relies on a number of relevant biomarkers, including EGFR , ALK , ROS-1, and PD-L1. Biomarker identification is most commonly based...

...Lester J. Layfield; Lauren Pearson; Brandon S. Walker; Sandra K. White; Robert L. Schmidt Objective: To determine the accuracy with which morphology alone can distinguish adenocarcinoma and squamous cell carcinoma in non-small cell lung cancer. Methods: We performed a systematic review and meta...

... Non-small cell lung cancer Core biopsy Lung cancer is the number one cause of cancer-related death in men and women in the USA [ 1,2,3 ]. Traditionally, lung carcinomas have been broadly divided into small cell carcinoma (SCC) and non-small cell lung carcinoma (NSCLC). NSCLC, which comprises...

...Edmond S.K. Ma; Wai-Kuen Ng; Chris L.P. Wong Activating mutations of the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer predicts a significantly higher clinical response rate to tyrosine kinase inhibitors targeting EGFR, and it is currently recommended that patients...

...Hillary Z. Kimbrell; Karen S. Gustafson; Min Huang; Hormoz Ehya Objectives: To determine the diagnostic accuracy of cytomorphology for subclassifying non-small cell lung cancer into adenocarcinoma (AC) and squamous cell carcinoma (SqC), and the utility of immunocytochemistry (ICC) for poorly...