...Yukiko Matsuo; Tsutomu Yoshida; Kazuya Yamashita; Yukitoshi Satoh Introduction: Liquid-based cytology (LBC) specimens of lung cancer are increasingly being used for genetic analyses. Preservation conditions of specimens until DNA extraction are important because they can affect DNA quality. We...

...Yoshiki Naito; Akihiko Kawahara; Ryo Makino; Takako Tokumitsu; Daisuke Nagayama; Eiji Sadashima; Kaori Nakamura; Ryoji Nishizaki; Tadasuke Nagatomo; Yukina Fujino; Chie Hayakawa; Keishi Mizuguchi; Tatsuya Mori; Kenichi Hirabayashi; Takuma Tajiri Introduction: The use of liquid-based cytology (LBC...

...Shabana Andleeb Ansari; Anshu Introduction: Cervical cancer screening using Pap smears is affected by false-negative results. Liquid-based cytology (LBC) offers the technical advantage of preparing cell blocks from residual fluid to conduct ancillary tests on them. The p16INK4a gene product has...

...) and telomerase reverse transcriptase (TERT) genes, in urine processed with liquid-based cytology (LBC) could enhance the diagnostic performance of cytology, particularly in defining the indeterminate categories of AUC and SHGUC. Methods: Urine samples from 82 UC patients with primary tumors or under surveillance...

[email protected] Cytological samples Immunocytochemistry Cell block Liquid-based cytology Cytological smears Validation protocols References 1. Metovic J , Righi L , Delsedime L , Volante M , Papotti M . Role of immunocytochemistry in the cytological diagnosis...

... diagnostic techniques have been applied, including immunocytochemistry (ICC). This review discusses the application and evaluation of ICC in thyroid fine needle aspiration. Summary: Currently, three immunostaining preparation methods are available for cytological materials: liquid-based cytology, cell block...

... analyses were conventionally performed using formalin-fixed paraffin-embedded sections rather than cytology samples such as cell block or smear specimens. Specimens collected from liquid-based cytology (LBC) have the potential to be sources of high-quality DNA suitable for genetic analysis even after long...

...: 0.57–0.84), with a cutoff value of 26 high-power field. Conclusion: Lymphocyte count using liquid-based cytology for patients with endometrial cancer may predict POLE mut plus MMR-d of TCGA groups and TMB-high in those who can benefit from immunotherapy. [email protected]...

... results of cases with an unsatisfactory ThinPrep Pap test and positive hrHPV results were revealed. Methods: Between January 1, 2018, and October 31, 2022, 965 (3.7%) of 25,958 liquid-based cytology specimens were evaluated as unsatisfactory. Ninety-five (9.8%) of 965 patients were positive for hrHPV...

...Nanako Sakabe; Sayumi Maruyama; Chihiro Ito; Yuka Shimoyama; Tetsuya Komene; Wataru Oboshi; Shouichi Sato; Kazuhisa Sudo; Katsuhide Ikeda Introduction: Liquid-based cytology (LBC)-fixed samples can be used for preparing multiple specimens of the same quality and for immunocytochemistry (ICC...

...Ji Eun Choi; Min-Sun Jin; Ilias P. Nikas; Han Suk Ryu Introduction: WellPrep® (WP), a fully automated, one-step liquid-based cytology (LBC) platform using an all-in-one closed chamber, has recently been developed as a next-generation LBC technology. This study aimed to evaluate the diagnostic...

... with the conventional preparation can be dissolved by liquid-based cytology (LBC) preparation. The Yokohama System is a method for reporting endometrial cytology, but the system lumps cancers together and does not distinguish between histological types. The objective of this study was to clarify morphometrical...

... and developed in the field of cytopathology. Liquid-based cytology (LBC) enables standardized cytological preparation and is also applied to artificial intelligence (AI) research, but cytological features differ depending on the LBC preservative solution types. In this study, the relationship between cell...

... in the cytological triage of human papillomavirus-positive women. Methods: A total of 147 HSIL samples of liquid-based cytology (LBC) in patients with cervical intraepithelial neoplasia grade 2 or 3 were obtained, and then, the relationship between cellular patterns, such as single-cell-like and syncytial aggregates...

... need for molecular testing on cytology specimens. The aim of this study was to determine the optimal preservation methods of liquid-based cytology (LBC) materials for molecular testing. Methods: Cytological samples from 35 surgical resected non-small cell lung carcinoma specimens were obtained between...

...) immunoenzyme staining combined with liquid-based cytology can serve as a noninvasive routine laboratory test for glomerular disease. Methods: The presence of PDX- and WT1-positive cells was investigated in 79 patients with glomerular disease and 51 patients with nonglomerular disease. Results: The frequencies...

... false negatives due to faulty smear preparations. Liquid-based cytology (LBC) can be advantageous in these scenarios. Hence, with an aim to investigate utility of LBC in these samples, we carried out the above study with objectives to find diagnostic accuracy of LBC and agreement of LBC with CS methods...

.... Cytopreparations Liquid-based cytology Serous effusions Serous effusions are peritoneal, pleural, pericardial fluids and intraoperative peritoneal washing fluids [1]. Normally, these cavities are collapsed and contain a small amount of fluid that enables the superimposed motion of the adjacent surfaces...

...Tzy Harn Chua; Khoon Leong Chuah Introduction: There is increasing need for more testing in non-small cell lung cancer given the introduction of newer targeted therapies. Cytological specimens including conventional smears (CS), cell blocks (CB), and liquid-based cytology (LBC) are an alternative...

...Katsuhide Ikeda; Wataru Oboshi; Yusuke Hashimoto; Tetsuya Komene; Yoshitaka Yamaguchi; Shouichi Sato; Sayumi Maruyama; Nozomi Furukawa; Nanako Sakabe; Kohzo Nagata Introduction: Liquid-based cytology (LBC) is increasingly used for nongynecologic applications. However, the cytological preparation...