Abstract
Introduction: The International Serous Fluid Cytopathology Reporting System (TIS) was developed to standardize communication among health professionals reporting analyses of serous fluid samples. The categories include non-diagnosis (ND), negative for malignancy (NFM), atypia of undetermined significance (AUS), suspected malignancy (SFM), and malignant (MAL). Each category was characterized by a risk of malignancy (ROM). Methods: We performed a literature review to analyze studies related to TIS using several sources, including PubMed, followed by a search of relevant cytopathology journal websites (American Cancer Society, Diagnostic Cytopathology, Journal of the American Society of Cytopathology, and Acta Cytologica and Cytopathology). The search included articles published between January 2020 and December 2023, using the terms “international AND serous fluid system.” Results: We identified 257 articles, of which 20 addressed the inclusion and exclusion criteria. The overall ROMs for each category were 23.55% for ND, 16.46% for NFM, 50.78% for AUS, 91.34% for SFM, and 98.21% for MAL. Conclusion: Considering the TIS-recommended ROM rates, the ND category was between the suggested intervals, while the SFM category rate was bigger than expected. The other categories (NFM, AUS, and MAL) were below expected values. SFM and MAL had a stronger association with MAL results. New studies are needed to determine each category’s ROM rate from TIS accurately.
Journal Section:
Nongynecologic Cytopathology
References
1.
Pinto
D
, Chandra
A
, Crothers
BA
, Kurtycz
DFI
, Schmitt
F
. The international system for reporting serous fluid cytopathology-diagnostic categories and clinical management
. J Am Soc Cytopathol
. 2020
;9
(6
):469
–77
. 2.
Ali
SZ
, Cibas
ES
. The Bethesda system for reporting thyroid cytopathology
. New York
: Springer
; 2010
.3.
Wojcik
EM
, Kurtycz
DFI
, Rosenthal
DL
. The Paris System for reporting urinary cytology
. Springer
. Vol. 2nd
; p. 2022
.4.
Faquin
WC
, Rossi
ED
. The Milan system for reporting salivary gland cytopathology
. Cham
: Springer
; 2018
.5.
Chandra
A
, Crothers
B
, Kurtycz
D
, Schmitt
F
. Announcement: the international system for reporting serous fluid cytopathology
. Acta Cytol
. 2019
;63
(5
):349
–51
. 6.
Lim
KH
, Ahmed
SS
, Cheng
XM
, Hwang
JSG
, Karunanithi
J
, Mantoo
S
, et al. A single tertiary institution review of the International system for serous fluid cytopathology and the impact of cell block and ancillary studies on its performance
. J Am Soc Cytopathol
. 2023
;12
(1
):48
–57
. 7.
Straccia
P
, Chiappetta
M
, Magnini
D
, Cancellieri
A
. Application of the International system for reporting serous fluid cytopathology (TIS): a retrospective institutional study
. Cytopathology
. 2022
;33
(3
):305
–11
. 8.
Kolte
S
, Zaheer
S
, Aden
D
, Ranga
S
. Application of the International system for reporting serous fluid cytopathology on reporting various body fluids; experience of a tertiary care hospital
. Cytojournal
. 2022
;19
:52
. 9.
Ahuja
S
, Malviya
A
. Categorisation of serous effusions using the International System for Reporting Serous Fluid Cytopathology and assessment of risk of malignancy with diagnostic accuracy
. Cytopathology
. 2022
;33
(2
):176
–84
. 10.
Sun
T
, Wang
M
, Wang
H
. Risk of malignancy assessment of the International system for Reporting serous fluid cytopathology: experience in a community hospital setting and comparison with other studies
. Cancer Cytopathol
. 2022
;130
(12
):964
–73
. 11.
Jha
S
, Sethy
M
, Adhya
AK
. Application of the International system for reporting serous fluid cytopathology in routine reporting of pleural effusion and assessment of the risk of malignancy
. Diagn Cytopathol
. 2021
;49
(10
):1089
–98
. 12.
Pergaris
A
, Stefanou
D
, Keramari
P
, Sousouris
S
, Kavantzas
N
, Gogas
H
, et al. Application of the International system for reporting serous fluid cytopathology with cytohistological correlation and risk of malignancy assessment
. Diagnostics
. 2021
;11
(12
):2223
. 13.
Zhu
YL
, Ren
WH
, Wang
Q
, Jin
HZ
, Guo
YY
, Lin
DM
. A retrospective analysis of serous effusions based on the newly proposed International system for reporting serous fluid cytopathology: a report of 3633 cases in an oncological center
. Diagn Pathol
. 2022
;17
(1
):56
. 14.
Bharti
S
, Nalwa
A
, Elhence
PA
, Rao
M
, Bharti
JN
, Khera
S
, et al. Risk stratification of pleural fluid cytology based on the International system for reporting serous fluid cytology in a tertiary care centre
. Acta Cytol
. 2022
;66
(5
):449
–56
. 15.
Wang
M
, Sun
T
, Jiao
J
, Wang
H
. Application of the International System for reporting serous fluid cytopathology to pericardial fluid: root cause analysis of indeterminate diagnoses, cytohistological correlation, and assessment of malignancy risk
. Cancer Cytopathol
. 2023
;131
(7
):433
–41
. 16.
Xu
Y
, Hu
AY
, Wang
SM
, Wang
Q
, Pan
YC
, Zhang
SH
. A retrospective analysis of pleural effusion specimens based on the newly proposed International system for reporting serous fluid cytopathology
. Diagn Cytopathol
. 2021
;49
(9
):997
–1007
. 17.
Lobo
C
, Costa
J
, Petronilho
S
, Monteiro
P
, Leça
L
, Schmitt
F
. Cytohistological correlation in serous effusions using the newly proposed International system for reporting serous fluid cytopathology: experience of an oncological center
. Diagn Cytopathol
. 2021
;49
(5
):596
–605
. 18.
Sachan
R
, Gupta
A
, Awasthi
PN
, Singh
P
, Anand
N
, Chandra
S
, et al. Application of International system for reporting serous fluid cytology (ISRSFC) in effusion samples-a prospective study in an oncology setting
. J Am Soc Cytopathol
. 2023
;12
(5
):351
–61
. 19.
Rakheja
G
, Singh
M
, Priyadarshnee
B
, Marimuthu
B
, Dhar
L
, Jain
S
, et al. Categorisation of peritoneal serous effusions using the International system for reporting serous fluid cytopathology-A study on gynaecological samples
. Cytopathology
. 2023
;34
(2
):138
–45
. 20.
Rajeswaran
PK
, Srinivasan
V
, Mahesh
SSV
, Ashok
AU
. A retrospective analysis of the application of the newly proposed International system for reporting serous fluid cytopathology on serous effusion specimens: an institutional experience
. Acta Cytol
. 2023
;67
(1
):70
–9
. 21.
Lu
CH
, Liu
CY
, Jhuang
JY
, Chen
CC
. Comprehensive evaluation of benign and malignant etiologies of different serous effusions with the International System for reporting serous fluid cytopathology: a multi-Institutional study in Taiwan
. Cancer Cytopathol
. 2024
;132
(3
):169
–78
. 22.
Kala
C
, Kala
S
, Singh
A
, Jauhari
RK
, Bajpai
A
, Khan
L
. The International system for reporting serous fluid cytopathology: an Institutional experience on its implication and assessment of risk of malignancy in effusion cytology
. J Cytol
. 2023
;40
(4
):159
–64
. 23.
Yang
H
, Zhu
J
, Wang
P
. Application of the International system for reporting serous fluid cytopathology (ISRSFC) in reporting serous effusion: a retrospective study
. Medicine
. 2023
;102
(43
):e35707
. 24.
Alashetty
S
, Sadasivan
B
, Dharmalingam
P
, Rajagopal
N
, Kavya
L
, Pai
MM
. The role of novel tiered reporting system in serous fluid cytology and risk of malignancy assessment: a retrospective study in a tertiary care center
. J Cytol
. 2023
;40
(3
):107
–13
. 25.
Pinto
D
, Cruz
E
, Branco
D
, Linares
C
, Carvalho
C
, Silva
A
, et al. Cytohistological correlation in pleural effusions based on the International system for reporting serous fluid cytopathology
. Diagnostics
. 2021
;11
(6
):1126
. 26.
Farahani
SJ
, Baloch
Z
. Are we ready to develop a tiered scheme for the effusion cytology? A comprehensive review and analysis of the literature
. Diagn Cytopathol
. 2019
;47
(11
):1145
–59
. 27.
Abouzgheib
W
, Bartter
T
, Dagher
H
, Pratter
M
, Klump
W
. A prospective study of the volume of pleural fluid required for accurate diagnosis of malignant pleural effusion
. Chest
. 2009
;135
(4
):999
–1001
. 28.
Rooper
LM
, Ali
SZ
, Olson
MT
. A minimum volume of more than 60 mL is necessary for adequate cytologic diagnosis of malignant pericardial effusions
. Am J Clin Pathol
. 2016
;145
(1
):101
–6
. 29.
Zhang
F
, Feng
Z
, Zhang
Y
, Liu
Z
, Sun
X
, Jin
S
. Determination of the optimal volume of ascitic fluid for the precise diagnosis of malignant ascites
. Saudi J Gastroenterol
. 2019 Sep-Oct
;25
(5
):327
–32
. 30.
Chandra
A
, Crothers
B
, Kurtycz
D
, Schmitt
F
. The International system for serous fluid cytopathology
. Nature Switzerland AG
: Springer
; 2020
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