Introduction: Core-needle biopsy (CNB) is a minimally invasive procedure used in preoperative diagnosis of breast lumps. It has been seen that in few years, the CNB seems to be replacing the fine-needle aspiration cytology (FNAC), although no study had yet conclusively proved a superiority of one over the other. Aims and Objectives: The aim of this study was to study the cytohistological spectrum of palpable breast lesions and to evaluate the diagnostic accuracy of FNAC versus CNB for breast lesions. Materials and Methods: The study was a cross-sectional study conducted in the Department of Pathology and Surgery, over a period of 1 year in 152 patients. All the patients were subjected to FNAC and CNB. Cytosmears were stained with May-Grunwald Giemsa and hematoxylin and eosin was done on CNB and excision biopsy (EB) specimens. Sensitivity and specificity were calculated in percentage with 95% confidence interval with reference to CNB/surgical specimens. Kappa statistics were used to compare the level of agreement between FNAC versus CNB and CNB versus surgical specimens. Results: A total of 152 patients were taken for FNAC and CNB. EB was performed in only 104 patients. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of FNAC verses CNB in correlation with subsequent histopathology were found to be (93.40 vs. 94.06%), (97.50 vs. 100.00%), (99.00 vs. 100.00%), (84.78 vs. 33.33%), and (94.52 vs. 94.23%), respectively. Conclusion: CNB has overcome the pitfall of FNAC but CNB cannot replace FNAC but both procedures are complementary to each other.

1.
Sung
H
,
Ferlay
J
,
Siegel
RL
,
Laversanne
M
,
Soerjomataram
I
,
Jemal
A
,
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
.
CA Cancer J Clin
.
2021
;
71
(
3
):
209
49
. .
2.
Rangarajan
B
,
Shet
T
,
Wadasadawala
T
,
Nair
NS
,
Sairam
RM
,
Hingmire
SS
,
Breast cancer: an overview of published Indian data
.
South Asian J Cancer
.
2016
;
5
:
86
92
. .
3.
Dikshit
R
,
Gupta
PC
,
Ramasundarahettige
C
,
Gajalakshmi
V
,
Aleksandrowicz
L
,
Badwe
R
,
Cancer mortality in India: a nationally representative survey
.
Lancet
.
2012
;
379
:
1807
16
. .
4.
Khokhar
A
.
Breast cancer in India: where do we stand and where do we go?
Asian Pac J Cancer Prev
.
2012
;
13
:
4861
6
. .
5.
Mitra
S
,
Dey
P
.
Fine-needle aspiration and core biopsy in the diagnosis of breast lesions: a comparison and review of the literature
.
CytoJournal
.
2016
;
13
:
18
. .
6.
NHSBSP
.
Guidelines for non operative diagnostic procedures and reporting in breast cancer screening
.
Sheffield
:
NHSBSP Publication No. 50
;
2001 Jun
.
7.
Kocaay
AF
,
Celik
SU
,
Sevim
Y
,
Ozyazici
S
,
Cetinkaya
OA
,
Alic
KB
.
The role of fine needle aspiration cytology and core biopsy in the diagnosis of palpable breast masses
.
Niger Med J
.
2016
;
57
:
77
80
. .
8.
Georgieva
RD
,
Obdeijn
IM
,
Jager
A
,
Hooning
MJ
,
Tilanus-Linthorst
MM
,
van Deurzen
CH
.
Breast fine-needle aspiration cytology performance in the high-risk screening population: a study of BRCA1/BRCA2 mutation carriers
.
Cancer Cytopathol
.
2013
;
121
:
561
7
. .
9.
Barra Ade
A
,
Gobbi
H
,
de L Rezende
CA
,
Gouvêa
AP
,
de Lucena
CE
,
Reis
JH
,
A comparision of aspiration cytology and core needle biopsy according to tumor size of suspicious breast lesions
.
Diagn Cytopathol
.
2008
;
36
:
26
31
.
10.
Willems
SM
,
van Deurzen
CH
,
van Diest
PJ
.
Diagnosis of breast lesions: fine-needle aspiration cytology or core needle biopsy? A review
.
J Clin Pathol
.
2012
;
65
:
287
92
. .
11.
Hukkinen
K
,
Kivisaari
L
,
Heikkilä
PS
,
Von Smitten
K
,
Leidenius
M
.
Unsuccessful preoperative biopsies, fine needle aspiration cytology or core needle biopsy, lead to increased costs in the diagnostic workup in breast cancer
.
Acta Oncol
.
2008
;
47
:
1037
45
. .
12.
Rakha
EA
,
Ellis
IO
.
An overview of assessment of prognostic and predictive factors in breast cancer needle core biopsy specimens
.
J Clin Pathol
.
2007
;
60
:
1300
6
. .
13.
Westenend
PJ
,
Sever
AR
,
Beekman-De Volder
HJ
,
Liem
SJ
.
A comparison of aspiration cytology and core needle biopsy in the evaluation of breast lesions
.
Cancer
.
2001
;
93
:
146
50
. .
14.
Barra Ade
A
,
Gobbi
H
,
de L Rezende
CA
,
Gouvêa
AP
,
de Lucena
CM
,
Reis
JH
,
A comparision of aspiration cytology and core needle biopsy according to tumor size of suspicious breast lesions
.
Diagn Cytopathol
.
2008
;
36
:
26
31
.
15.
Sun
W
,
Li
A
,
Abreo
F
,
Turbat-Herrera
E
,
Grafton
WD
.
Comparison of fine-needle aspiration cytology and core biopsy for diagnosis of breast cancer
.
Diagn Cytopathol
.
2001
;
24
:
421
5
. .
16.
Hatada
T
,
Ishii
H
,
Ichii
S
,
Okada
K
,
Fujiwara
Y
,
Yamamura
T
.
Diagnostic value of ultrasound-guided fine-needle aspiration biopsy, core-needle biopsy, and evaluation of combined use in the diagnosis of breast lesions
.
J Am Coll Surg
.
2000
;
190
:
299
303
. .
17.
Willems
SM
,
van Deurzen
CH
,
van Diest
PJ
.
Diagnosis of breast lesions: fine-needle aspiration cytology or core needle biopsy? A review
.
J Clin Pathol
.
2012
;
65
:
287
92
. .
18.
Wang
M
,
He
X
,
Chang
Y
,
Sun
G
,
Thabane
L
.
A sensitivity and specificity comparison of fine needle aspiration cytology and core needle biopsy in evaluation of suspicious breast lesions: a systematic review and meta-analysis
.
Breast
.
2017 Feb
;
31
:
157
66
. .
19.
Chakrabarti
I
.
FNAC versus CNB: who wins the match in breast lesions?
J Cytol
.
2018
;
35
:
176
8
. .
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