Objective: The aim of the study was to study the clinical and morphological spectrum of histoplasmosis diagnosed by fine needle aspiration cytology (FNAC). Study Design: A total of 17 patients diagnosed with histoplasmosis on FNAC were studied over a period of 5 years. The cytology smears were studied and analysed for the cytomorphological spectrum of histoplasmosis. Results: Among the 17 patients studied, the mean age was 51.3 years (range 6–84 years). Male-to-female ratio was 3.25:1 with 4 females and 13 males. The frequent sites of involvement were the lung (5), lymph node (4), adrenal gland (4), and skin (4). The most common cytological patterns were histiocytic collection, followed by granulomas and multinucleated giant cells. Necrosis was noted in only 4 cases. Conclusion: Fine needle aspiration is a highly accurate, rapid, and cheap technique for the diagnosis of histoplasmosis due to its distinct morphological features.

1.
Darling
ST
.
A protozoan general infection producing pseudotubercles in the lungs and focal necrosis in the liver, spleen and lymphnodes
.
J Am Med Assoc
.
1906
;
46
:
1283
5
.
2.
Deepe
GS
 Jr
.
Histoplasma capsulatum
. In:
Mandell
GL
,
Benett
JE
,
Dolin
R
, editors.
Mandell, Douglas and Bennett’s principles and practice of infectious diseases
.
Philadelphia
:
Churchill Livingstone
;
2000
. p.
2718
32
.
3.
Gopalakrishnan
R
,
Senthur Nambi
P
,
Ramasubramanian
V
,
Abdul Ghafur
K
,
Parameswaran
A
.
Histoplasmosis in India: truly uncommon or uncommonly recognized?
J Assoc Phys India
.
2012
;
60
:
25
8
.
4.
Antinori
S
.
Histoplasma capsulatum: more widespread than previously thought
.
Am J Trop Med Hyg
.
2014
;
90
(
6
):
982
983
. .
5.
Sanyal
M
,
Thammayya
A
.
Histoplasma capsulatum in the soil of Gangetic Plain in India
.
Indian J Med Res
.
1975
;
63
:
1020
1028
.
6.
Panja
G
,
Sen
S
.
A unique case of histoplasmosis
.
J Indian Med Assoc
.
1954
;
23
:
257
8
.
7.
Chande
C
,
Menon
S
,
Gohil
A
,
Lilani
S
,
Bade
J
,
Mohammad
S
, et al
Cutaneous histoplasmosis in AIDS
.
Indian J Med Microbiol
.
2010
;
28
:
404
6
.
8.
Randhawa
HS
,
Gugnani
HC
.
Occurrence of histoplasmosis in the Indian Sub-continent: an overview and update
.
J Med Res Prac
.
2018
;
7
(
3
):
71
83
.
9.
Gajendra
S
,
Sharma
R
,
Goel
S
,
Goel
R
,
Lipi
L
,
Sarin
H
, et al
Adrenal histoplasmosis in immunocompetent patients presenting as adrenal insufficiency
.
Turk Patoloji Derg
.
2016
;
32
:
105
11
.
10.
Grover
SB
,
Midha
N
,
Gupta
M
,
Sharma
U
,
Talib
VH
.
Imaging spectrum in disseminated histoplasmosis: case report and brief review
.
Australas Radiol
.
2005
;
49
:
175
8
.
11.
Gupta
N
,
Arora
SK
,
Rajwanshi
A
,
Nijhawan
R
,
Srinivasan
R
.
Histoplasmosis: cytodiagnosis and review of literature with special emphasis on differential diagnosis on cytomorphology
.
Cytopathology
.
2010
;
21
:
240
4
.
12.
Gailey
MP
,
Klutts
JS
,
Jensen
CS
.
Fine-needle aspiration of histoplasmosis in the era of endoscopic ultrasound and endobronchial ultrasound
.
Cancer Cytopathol
.
2013 Sep
;
121
(
9
):
508
17
.
13.
Jaiswal
S
,
Viz
M
,
Chand
G
,
Misra
R
,
Pandey
R
.
Diagnosis of adrenal histoplasmosis by fine needle aspiration cytology: an analysis based on five cases
.
Cytopathology
.
2011
;
22
:
323
8
.
14.
Singh
RR
.
Adrenal histoplasmosis diagnosed by endoscopic ultrasound guided fine needle aspiration: experience of 10 patients
.
Trop Gastroenterol
.
2017
;
38
(
2
):
96
101
.
15.
Larbcharoensub
N
,
Boonsakan
P
,
Aroonroch
R
,
Rochanawutanon
M
,
Nitiyanant
P
,
Phongkitkarun
S
, et al
Adrenal histoplasmosis: a case series and review of the literature
.
Southeast Asian J Trop Med Public Health
.
2011 Jul
;
42
(
4
):
920
5
.
16.
Gupta
P
,
Bhardwaj
M
.
Cytodiagnosis of disseminated histoplasmosis in an immunocompetent individual with molluscum contagiosum-like skin lesions and lymphadenopathy
.
J Cytol
.
2016
;
33
:
163
5
.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.