Abstract
Salivary gland tumor aspiration cytology is a useful preoperative test to guide the most appropriate clinical and surgical management for these patients. Although salivary gland cytology is often useful to distinguish between non-neoplastic lesions, benign neoplasms and malignant neoplasms, there remain many challenges in this area. Specifically, these tumors are uncommon and may have considerable morphologic overlap, especially in the setting of a malignant tumor. This article reviews some of the immunohistochemical and molecular characteristics of more common salivary gland neoplasms that pathologists and cytotechnologists may encounter. When used in combination with morphologic features, such ancillary testing can be useful to further refine the differential diagnosis, more strongly favor a particular entity, or in some instances confidently provide a specific diagnosis.
References
1.
Schmidt
RL
, Hall
BJ
, Wilson
AR
, Layfield
LJ
. A systematic review and meta-analysis of the diagnostic accuracy of fine-needle aspiration cytology for parotid gland lesions
. Am J Clin Pathol
. 2011
Jul
;136
(1
):45
–59
.
[PubMed]
0002-91732.
Mairembam
P
, Jay
A
, Beale
T
, Morley
S
, Vaz
F
, Kalavrezos
N
, et al Salivary gland FNA cytology: role as a triage tool and an approach to pitfalls in cytomorphology
. Cytopathology
. 2016
Apr
;27
(2
):91
–6
.
[PubMed]
0956-55073.
Pusztaszeri
M
, Baloch
Z
, Vielh
P
, Faquin
WC
. Application of the Milan system for reporting risk stratification in salivary gland cytopathology
. Cancer Cytopathol
. 2018
Jan
;126
(1
):69
–70
.
[PubMed]
1934-662X4.
Griffith
CC
, Schmitt
AC
, Pantanowitz
L
, Monaco
SE
. A pattern-based risk-stratification scheme for salivary gland cytology: A multi-institutional, interobserver variability study to determine applicability
. Cancer Cytopathol
. 2017
Oct
;125
(10
):776
–85
.
[PubMed]
1934-662X5.
Griffith
CC
, Pai
RK
, Schneider
F
, Duvvuri
U
, Ferris
RL
, Johnson
JT
, et al Salivary gland tumor fine-needle aspiration cytology: a proposal for a risk stratification classification
. Am J Clin Pathol
. 2015
Jun
;143
(6
):839
–53
.
[PubMed]
0002-91736.
Martins
C
, Fonseca
I
, Roque
L
, Pereira
T
, Ribeiro
C
, Bullerdiek
J
, et al PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry
. Mod Pathol
. 2005
Aug
;18
(8
):1048
–55
.
[PubMed]
0893-39527.
Kas
K
, Voz
ML
, Röijer
E
, Aström
AK
, Meyen
E
, Stenman
G
, et al Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations
. Nat Genet
. 1997
Feb
;15
(2
):170
–4
.
[PubMed]
1061-40368.
Voz
ML
, Aström
AK
, Kas
K
, Mark
J
, Stenman
G
, Van de Ven
WJ
. The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter
. Oncogene
. 1998
Mar
;16
(11
):1409
–16
.
[PubMed]
0950-92329.
Matsuyama A, Hisaoka M, Nagao Y, Hashimoto H. Aberrant PLAG1 expression in pleomorphic adenomas of the salivary gland: a molecular genetic and immunohistochemical study. Virchows Arch. 2011 May;458(5):583–92.
10.
Katabi
N
, Xu
B
, Jungbluth
AA
, Zhang
L
, Shao
SY
, Lane
J
, et al PLAG1 immunohistochemistry is a sensitive marker for pleomorphic adenoma: a comparative study with PLAG1 genetic abnormalities
. Histopathology
. 2018
Jan
;72
(2
):285
–93
.
[PubMed]
0309-016711.
Kandasamy
J
, Smith
A
, Diaz
S
, Rose
B
, O’Brien
C
. Heterogeneity of PLAG1 gene rearrangements in pleomorphic adenoma
. Cancer Genet Cytogenet
. 2007
Aug
;177
(1
):1
–5
.
[PubMed]
0165-460812.
Rotellini
M
, Palomba
A
, Baroni
G
, Franchi
A
. Diagnostic utility of PLAG1 immunohistochemical determination in salivary gland tumors
. Appl Immunohistochem Mol Morphol
. 2014
May-Jun
;22
(5
):390
–4
.
[PubMed]
1541-201613.
Bahrami
A
, Dalton
JD
, Shivakumar
B
, Krane
JF
. PLAG1 alteration in carcinoma ex pleomorphic adenoma: immunohistochemical and fluorescence in situ hybridization studies of 22 cases
. Head Neck Pathol
. 2012
Sep
;6
(3
):328
–35
.
[PubMed]
1936-055X14.
Persson
F
, Andrén
Y
, Winnes
M
, Wedell
B
, Nordkvist
A
, Gudnadottir
G
, et al High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2
. Genes Chromosomes Cancer
. 2009
Jan
;48
(1
):69
–82
.
[PubMed]
1045-225715.
Bahrami
A
, Perez-Ordonez
B
, Dalton
JD
, Weinreb
I
. An analysis of PLAG1 and HMGA2 rearrangements in salivary duct carcinoma and examination of the role of precursor lesions
. Histopathology
. 2013
Aug
;63
(2
):250
–62
.
[PubMed]
0309-016716.
Katabi
N
, Ghossein
R
, Ho
A
, Dogan
S
, Zhang
L
, Sung
YS
, et al Consistent PLAG1 and HMGA2 abnormalities distinguish carcinoma ex-pleomorphic adenoma from its de novo counterparts
. Hum Pathol
. 2015
Jan
;46
(1
):26
–33
.
[PubMed]
0046-817717.
Bilodeau
EA
, Acquafondata
M
, Barnes
EL
, Seethala
RR
. A comparative analysis of LEF-1 in odontogenic and salivary tumors
. Hum Pathol
. 2015
Feb
;46
(2
):255
–9
.
[PubMed]
0046-817718.
Schmitt
AC
, Griffith
CC
, Cohen
C
, Siddiqui
MT
. LEF-1: diagnostic utility in distinguishing basaloid neoplasms of the salivary gland
. Diagn Cytopathol
. 2017
Dec
;45
(12
):1078
–83
.
[PubMed]
8755-103919.
Tabatabai
ZL
, Auger
M
, Kurtycz
DF
, Laser
A
, Souers
RJ
, Laucirica
R
, et al Performance Characteristics of Adenoid Cystic Carcinoma of the Salivary Glands in Fine-Needle Aspirates: Results From the College of American Pathologists Nongynecologic Cytology Program
. Arch Pathol Lab Med
. 2015
Dec
;139
(12
):1525
–30
.
[PubMed]
0003-998520.
Mino
M
, Pilch
BZ
, Faquin
WC
. Expression of KIT (CD117) in neoplasms of the head and neck: an ancillary marker for adenoid cystic carcinoma
. Mod Pathol
. 2003
Dec
;16
(12
):1224
–31
.
[PubMed]
0893-395221.
West
RB
, Kong
C
, Clarke
N
, Gilks
T
, Lipsick
JS
, Cao
H
, et al MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation
. Am J Surg Pathol
. 2011
Jan
;35
(1
):92
–9
.
[PubMed]
0147-518522.
Mitani
Y
, Li
J
, Rao
PH
, Zhao
YJ
, Bell
D
, Lippman
SM
, et al Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance
. Clin Cancer Res
. 2010
Oct
;16
(19
):4722
–31
.
[PubMed]
1078-043223.
Hudson
JB
, Collins
BT
. MYB gene abnormalities t(6;9) in adenoid cystic carcinoma fine-needle aspiration biopsy using fluorescence in situ hybridization
. Arch Pathol Lab Med
. 2014
Mar
;138
(3
):403
–9
.
[PubMed]
0003-998524.
Higashi
K
, Jin
Y
, Johansson
M
, Heim
S
, Mandahl
N
, Biörklund
A
, et al Rearrangement of 9p13 as the primary chromosomal aberration in adenoid cystic carcinoma of the respiratory tract
. Genes Chromosomes Cancer
. 1991
Jan
;3
(1
):21
–3
.
[PubMed]
1045-225725.
Nordkvist
A
, Mark
J
, Gustafsson
H
, Bang
G
, Stenman
G
. Non-random chromosome rearrangements in adenoid cystic carcinoma of the salivary glands
. Genes Chromosomes Cancer
. 1994
Jun
;10
(2
):115
–21
.
[PubMed]
1045-225726.
Persson
M
, Andrén
Y
, Mark
J
, Horlings
HM
, Persson
F
, Stenman
G
. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck
. Proc Natl Acad Sci USA
. 2009
Nov
;106
(44
):18740
–4
.
[PubMed]
0027-842427.
Brill
LB
2nd, Kanner
WA
, Fehr
A
, Andrén
Y
, Moskaluk
CA
, Löning
T
, et al Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms
. Mod Pathol
. 2011
Sep
;24
(9
):1169
–76
.
[PubMed]
0893-395228.
Rooney
SL
, Robinson
RA
: Immunohistochemical expression of MYB in salivary gland basal cell adenocarcinoma and basal cell adenoma.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2017
;46:798-802. 29.
Pusztaszeri
MP
, Faquin
WC
. MYB is a helpful diagnostic marker for adenoid cystic carcinoma in fine-needle aspiration biopsy
. Arch Pathol Lab Med
. 2015
Feb
;139
(2
):157
–8
.
[PubMed]
0003-998530.
Chênevert
J
, Duvvuri
U
, Chiosea
S
, Dacic
S
, Cieply
K
, Kim
J
, et al DOG1: a novel marker of salivary acinar and intercalated duct differentiation
. Mod Pathol
. 2012
Jul
;25
(7
):919
–29
.
[PubMed]
0893-395231.
Schmitt
AC
, Cohen
C
, Siddiqui
MT
. Expression of SOX10 in Salivary Gland Oncocytic Neoplasms: A Review and a Comparative Analysis with Other Immunohistochemical Markers
. Acta Cytol
. 2015
;59
(5
):384
–90
.
[PubMed]
0001-554732.
Ohtomo
R
, Mori
T
, Shibata
S
, Tsuta
K
, Maeshima
AM
, Akazawa
C
, et al SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology
. Inc
. 2013
;26
:1041
–50
.33.
Deal
KK
, Cantrell
VA
, Chandler
RL
, Saunders
TL
, Mortlock
DP
, Southard-Smith
EM
. Distant regulatory elements in a Sox10-beta GEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest-derived tissues
. Dev Dyn
. 2006
May
;235
(5
):1413
–32
.
[PubMed]
1058-838834.
Khurram
SA
, Speight
PM
. Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers
. Head Neck Pathol
. 2018
Apr
.
[PubMed]
1936-055X35.
Thompson
LD
, Aslam
MN
, Stall
JN
, Udager
AM
, Chiosea
S
, McHugh
JB
. Clinicopathologic and Immunophenotypic Characterization of 25 Cases of Acinic Cell Carcinoma with High-Grade Transformation
. Head Neck Pathol
. 2016
Jun
;10
(2
):152
–60
.
[PubMed]
1936-055X36.
Bajaj
J
, Gimenez
C
, Slim
F
, Aziz
M
, Das
K
. Fine-needle aspiration cytology of mammary analog secretory carcinoma masquerading as low-grade mucoepidermoid carcinoma: case report with a review of the literature
. Acta Cytol
. 2014
;58
(5
):501
–10
.
[PubMed]
0001-554737.
Griffith
CC
, Stelow
EB
, Saqi
A
, Khalbuss
WE
, Schneider
F
, Chiosea
SI
, et al The cytological features of mammary analogue secretory carcinoma: a series of 6 molecularly confirmed cases
. Cancer Cytopathol
. 2013
May
;121
(5
):234
–41
.
[PubMed]
1934-662X38.
Higuchi
K
, Urano
M
, Takahashi
RH
, Oshiro
H
, Matsubayashi
J
, Nagai
T
, et al Cytological features of mammary analogue secretory carcinoma of salivary gland: fine-needle aspiration of seven cases
. Diagn Cytopathol
. 2014
Oct
;42
(10
):846
–55
.
[PubMed]
8755-103939.
Skálová
A
, Vanecek
T
, Sima
R
, Laco
J
, Weinreb
I
, Perez-Ordonez
B
, et al Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity
. Am J Surg Pathol
. 2010
May
;34
(5
):599
–608
.
[PubMed]
1532-097940.
Bishop
JA
, Yonescu
R
, Batista
D
, Begum
S
, Eisele
DW
, Westra
WH
. Utility of mammaglobin immunohistochemistry as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma
. Hum Pathol
. 2013
Oct
;44
(10
):1982
–8
.
[PubMed]
0046-817741.
Patel
KR
, Solomon
IH
, El-Mofty
SK
, Lewis
JS
Jr, Chernock
RD
. Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma
. Hum Pathol
. 2013
Nov
;44
(11
):2501
–8
.
[PubMed]
0046-817742.
Kawahara
A
, Taira
T
, Abe
H
, Takase
Y
, Kurita
T
, Sadashima
E
, et al Diagnostic utility of phosphorylated signal transducer and activator of transcription 5 immunostaining in the diagnosis of mammary analogue secretory carcinoma of the salivary gland: A comparative study of salivary gland cancers
. Cancer Cytopathol
. 2015
Oct
;123
(10
):603
–11
.
[PubMed]
1934-662X43.
Chiosea
SI
, Griffith
C
, Assaad
A
, Seethala
RR
. Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands
. Histopathology
. 2012
Sep
;61
(3
):387
–94
.
[PubMed]
0309-016744.
Ito
Y
, Ishibashi
K
, Masaki
A
, Fujii
K
, Fujiyoshi
Y
, Hattori
H
, et al Mammary analogue secretory carcinoma of salivary glands: a clinicopathologic and molecular study including 2 cases harboring ETV6-X fusion
. Am J Surg Pathol
. 2015
May
;39
(5
):602
–10
.
[PubMed]
0147-518545.
Skálová
A
, Vanecek
T
, Simpson
RH
, Laco
J
, Majewska
H
, Baneckova
M
, et al Mammary Analogue Secretory Carcinoma of Salivary Glands: Molecular Analysis of 25 ETV6 Gene Rearranged Tumors With Lack of Detection of Classical ETV6-NTRK3 Fusion Transcript by Standard RT-PCR: Report of 4 Cases Harboring ETV6-X Gene Fusion
. Am J Surg Pathol
. 2016
Jan
;40
(1
):3
–13
.
[PubMed]
0147-518546.
Rooper
LM
, Karantanos
T
, Ning
Y
, Bishop
JA
, Gordon
SW
, Kang
H
. Salivary Secretory Carcinoma With a Novel ETV6-MET Fusion: Expanding the Molecular Spectrum of a Recently Described Entity
. Am J Surg Pathol
. 2018
Aug
;42
(8
):1121
–6
.
[PubMed]
0147-518547.
Skalova
A
, Vanecek
T
, Martinek
P
, Weinreb
I
, Stevens
TM
, Simpson
RH
, et al Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: report of 10 Cases
. Am J Surg Pathol
. 2018
Feb
;42
(2
):234
–46
.
[PubMed]
0147-518548.
Klijanienko
J
, El-Naggar
AK
, Vielh
P
. Fine-needle sampling findings in 26 carcinoma ex pleomorphic adenomas: diagnostic pitfalls and clinical considerations
. Diagn Cytopathol
. 1999
Sep
;21
(3
):163
–6
.
[PubMed]
8755-103949.
Nakayama
T
, Miyabe
S
, Okabe
M
, Sakuma
H
, Ijichi
K
, Hasegawa
Y
, et al Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology
. Inc
. 2009
;22
:1575
–81
.50.
Fehr
A
, Röser
K
, Heidorn
K
, Hallas
C
, Löning
T
, Bullerdiek
J
. A new type of MAML2 fusion in mucoepidermoid carcinoma
. Genes Chromosomes Cancer
. 2008
Mar
;47
(3
):203
–6
.
[PubMed]
1045-225751.
Tonon
G
, Modi
S
, Wu
L
, Kubo
A
, Coxon
AB
, Komiya
T
, et al t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway
. Nat Genet
. 2003
Feb
;33
(2
):208
–13
.
[PubMed]
1061-403652.
Chenevert
J
, Barnes
LE
, Chiosea
SI
: Mucoepidermoid carcinoma: a five-decade journey.
Virchows Archiv : an international journal of pathology 2011
;458:133-140. 53.
Kass
JI
, Lee
SC
, Abberbock
S
, Seethala
RR
, Duvvuri
U
. Adenosquamous carcinoma of the head and neck: molecular analysis using CRTC-MAML FISH and survival comparison with paired conventional squamous cell carcinoma
. Laryngoscope
. 2015
Nov
;125
(11
):E371
–6
.
[PubMed]
0023-852X54.
Seethala
RR
, Dacic
S
, Cieply
K
, Kelly
LM
, Nikiforova
MN
. A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas
. Am J Surg Pathol
. 2010
Aug
;34
(8
):1106
–21
.
[PubMed]
0147-518555.
Tirado
Y
, Williams
MD
, Hanna
EY
, Kaye
FJ
, Batsakis
JG
, El-Naggar
AK
. CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin’s tumors: implications for histogenesis and biologic behavior
. Genes Chromosomes Cancer
. 2007
Jul
;46
(7
):708
–15
.
[PubMed]
1045-225756.
Clauditz
TS
, Gontarewicz
A
, Wang
CJ
, Münscher
A
, Laban
S
, Tsourlakis
MC
, et al 11q21 rearrangement is a frequent and highly specific genetic alteration in mucoepidermoid carcinoma
. Diagn Mol Pathol
. 2012
Sep
;21
(3
):134
–7
.
[PubMed]
1052-955157.
Fehr
A
, Röser
K
, Belge
G
, Löning
T
, Bullerdiek
J
. A closer look at Warthin tumors and the t(11;19)
. Cancer Genet Cytogenet
. 2008
Jan
;180
(2
):135
–9
.
[PubMed]
0165-460858.
Ishibashi
K
, Ito
Y
, Masaki
A
, Fujii
K
, Beppu
S
, Sakakibara
T
, et al Warthin-like Mucoepidermoid Carcinoma: A Combined Study of Fluorescence In Situ Hybridization and Whole-slide Imaging
. Am J Surg Pathol
. 2015
Nov
;39
(11
):1479
–87
.
[PubMed]
0147-518559.
Martins
C
, Cavaco
B
, Tonon
G
, Kaye
FJ
, Soares
J
, Fonseca
I
. A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin’s tumor of salivary glands
. J Mol Diagn
. 2004
Aug
;6
(3
):205
–10
.
[PubMed]
1525-157860.
Okabe
M
, Miyabe
S
, Nagatsuka
H
, Terada
A
, Hanai
N
, Yokoi
M
, Shimozato
K
, Eimoto
T
, Nakamura
S
, Nagai
N
, Hasegawa
Y
, Inagaki
H
: MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006
;12:3902-3907. 61.
Weinreb
I
, Seethala
RR
, Perez-Ordoñez
B
, Chetty
R
, Hoschar
AP
, Hunt
JL
. Oncocytic mucoepidermoid carcinoma: clinicopathologic description in a series of 12 cases
. Am J Surg Pathol
. 2009
Mar
;33
(3
):409
–16
.
[PubMed]
0147-518562.
García
JJ
, Hunt
JL
, Weinreb
I
, McHugh
JB
, Barnes
EL
, Cieply
K
, et al Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test
. Hum Pathol
. 2011
Dec
;42
(12
):2001
–9
.
[PubMed]
0046-817763.
Bishop
JA
, Cowan
ML
, Shum
CH
, Westra
WH
. MAML2 Rearrangements in Variant Forms of Mucoepidermoid Carcinoma: Ancillary Diagnostic Testing for the Ciliated and Warthin-like Variants
. Am J Surg Pathol
. 2018
Jan
;42
(1
):130
–6
.
[PubMed]
1532-097964.
Williams
L
, Thompson
LD
, Seethala
RR
, Weinreb
I
, Assaad
AM
, Tuluc
M
, et al Salivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression
. Am J Surg Pathol
. 2015
May
;39
(5
):705
–13
.
[PubMed]
0147-518565.
Yeoh
CC
, Dabab
N
, Rigby
E
, Chhikara
R
, Akaev
I
, Gomez
RS
, et al Androgen receptor in salivary gland carcinoma: A review of an old marker as a possible new target
. J Oral Pathol Med
. 2018
Aug
;47
(7
):691
–5
.
[PubMed]
0904-251266.
Udager
AM
, Chiosea
SI
. Salivary Duct Carcinoma: An Update on Morphologic Mimics and Diagnostic Use of Androgen Receptor Immunohistochemistry
. Head Neck Pathol
. 2017
Sep
;11
(3
):288
–94
.
[PubMed]
1936-055X67.
Stevens
TM
, Kovalovsky
AO
, Velosa
C
, Shi
Q
, Dai
Q
, Owen
RP
, et al Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study. Modern pathology : an official journal of the United States and Canadian Academy of Pathology
. Inc
. 2015
;28
:1084
–100
.68.
Jalaly
JB
, Sanati
S
, Chernock
RD
, Dibe
DG
, El-Mofty
SK
. Salivary Duct Carcinoma and Invasive Ductal Carcinoma of the Breast: A Comparative Immunohistochemical Study
. Head Neck Pathol
. 2018
Dec
;12
(4
):488
–92
.
[PubMed]
1936-055X69.
Can
NT
, Lingen
MW
, Mashek
H
, McElherne
J
, Briese
R
, Fitzpatrick
C
, et al Expression of Hormone Receptors and HER-2 in Benign and Malignant Salivary Gland Tumors
. Head Neck Pathol
. 2018
Mar
;12
(1
):95
–104
.
[PubMed]
1936-055X70.
Boon
E
, Bel
M
, van Boxtel
W
, van der Graaf
WT
, van Es
RJ
, Eerenstein
SE
, et al; PALGA Group
. A clinicopathological study and prognostic factor analysis of 177 salivary duct carcinoma patients from The Netherlands
. Int J Cancer
. 2018
Aug
;143
(4
):758
–66
.
[PubMed]
0020-713671.
Gilbert
MR
, Sharma
A
, Schmitt
NC
, Johnson
JT
, Ferris
RL
, Duvvuri
U
, et al A 20-Year Review of 75 Cases of Salivary Duct Carcinoma
. JAMA Otolaryngol Head Neck Surg
. 2016
May
;142
(5
):489
–95
.
[PubMed]
2168-618172.
Corrêa
TS
, Matos
GD
, Segura
M
, Dos Anjos
CH
. Second-Line Treatment of HER2-Positive Salivary Gland Tumor: Ado-Trastuzumab Emtansine (T-DM1) after Progression on Trastuzumab
. Case Rep Oncol
. 2018
May
;11
(2
):252
–7
.
[PubMed]
1662-657573.
Thorpe
LM
, Schrock
AB
, Erlich
RL
, Miller
VA
, Knost
J
, Le-Lindqwister
N
, et al Significant and durable clinical benefit from trastuzumab in 2 patients with HER2-amplified salivary gland cancer and a review of the literature
. Head Neck
. 2017
Mar
;39
(3
):E40
–4
.
[PubMed]
1043-307474.
van Boxtel
W
, Boon
E
, Weijs
WL
, van den Hoogen
FJ
, Flucke
UE
, van Herpen
CM
. Combination of docetaxel, trastuzumab and pertuzumab or treatment with trastuzumab-emtansine for metastatic salivary duct carcinoma
. Oral Oncol
. 2017
Sep
;72
:198
–200
.
[PubMed]
1368-837575.
Boon
E
, van Boxtel
W
, Buter
J
, Baatenburg de Jong
RJ
, van Es
RJ
, Bel
M
, et al; Nationwide Network and Registry of Histopathology and Cytopathology (PALGA) Group
. Androgen deprivation therapy for androgen receptor-positive advanced salivary duct carcinoma: A nationwide case series of 35 patients in The Netherlands
. Head Neck
. 2018
Mar
;40
(3
):605
–13
.
[PubMed]
1043-3074© 2019 S. Karger AG, Basel
2019
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