Objective: Basal cell adenoma (BCA) is an uncommon benign epithelial neoplasm of salivary glands, which was first described by Kleinsasser and Klein in 1967 and which derives its name from the monomorphic basaloid appearance of tumor cells. This tumor represents 1–2% of all salivary gland epithelial tumors; the most common site of occurrence is the parotid gland. It usually arises in adults over 50 years of age with slight female prevalence. Study Design: We analyzed 5 cases of parotid lesions investigated by fine needle aspiration cytology at a single institution between 2002 and 2018. Results: Our series was composed by 3 women and 2 men with a mean age of 62 years. The most important cytological criteria we observed were cohesive sharp-angled clusters of regular basaloid cells, palisaded by p63-positive myoepi-thelial cells, and bordered by basement membrane-like hyaline membrane in the absence of a myxochondroid stroma. Overall features were consistent with the diagnosis of BCA. Conclusions: Our aim is to highlight the cytological features of these rare lesions improving the awareness of cytological pitfalls of salivary gland basaloid neoplasms. Moreover, the goal of this paper is to add to the literature 5 additional cases of these unusual tumors.

El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ: WHO Classification of Head and Neck Tumours, ed 4. Lyon, IARC Press, 2017.
Bhat A, Rao M, Geethamani V, Shetty AC: Basal cell adenoma of the parotid gland: cytological diagnosis of an uncommon tumor. J Oral Maxillofac Pathol 2015; 19: 106.
Lu J, Zhang W, Wang Z, et al: Basal cell adenoma of the parotid gland: clinical and pathological findings in 29 cases. Int J Clin Exp Pathol 2015; 8: 2899–2908.
Rajasenthil V, Ravi A: Basal cell adenoma of the parotid gland – a rare entity. Indian J Surg 2014; 76: 408–410.
Kanaujia SK, Singh A, Nautiyal S, Ashutosh K: Basal cell adenoma of parotid gland: case report and review of literature. Indian J Otolaryngol Head Neck Surg 2015; 67: 430–433.
Kawahara A, Harada H, Akiba J, Yokoyama T, Kage M: Fine-needle aspiration cytology of basal cell adenoma of the parotid gland: characteristic cytological features and diagnostic pitfalls. Diagn Cytopathol 2007; 35: 85–90.
Faquin WC, Powers CN: Salivary Gland Cytopathology. New York, Springer, 2008.
Kleinsasser O, Klein HJ: Basal cell adenoma of the salivary glands. Arch Klin Exp Ohren Na-sen Kehlkopfheilkd 1967; 189: 302–316.
Lambade PN, Rajkhokar D, Lambade D: Basal cell adenoma of submandibular salivary gland: a case report and literature review. J Maxillofac Oral Surg 2015; 14: 999–1003.
Seethala RR, Stenman G: Update from the 4th edition of the World Health Organization classification of head and neck tumours: tumors of the salivary gland. Head Neck Pathol 2017; 11: 55–67.
Shetty A, Geethamani V: Role of fine-needle aspiration cytology in the diagnosis of major salivary gland tumors: a study with histological and clinical correlation. J Oral Maxillofac Pathol 2016; 20: 224–229.
Nur M, Murphy M: Adequacy and accuracy of salivary gland fine needle aspiration cytology. Ir J Med Sci 2016 185: 711–716.
Daneshbod Y, Daneshbod K, Khademi B: Diagnostic difficulties in the interpretation of fine needle aspirate samples in salivary lesions: diagnostic pitfalls revisited. Acta Cytol 2009; 53: 53–70.
Zurczyk M, Peevey JF, Vande Haar MA, Lin X: Pitfalls of fine-needle aspiration cytology of parotid membranous basal cell adenoma – a review of pitfalls in FNA cytology of salivary gland neoplasms with basaloid cell features. Diagn Cytopathol 2014; 43: 432–437.
Gupta N, Bal A, Gupta AK, Rajwanshi A: Basal cell adenoma: a diagnostic dilemma on fine needle aspiration cytology. Diagn Cytopathol 2011; 39: 913–916.
Kazakov DV: Brooke-Spiegler syndrome and phenotypic variants: an update. Head Neck Pathol 2016; 10: 125–130.
Schmitt AC, Griffith CC, Cohen C, Siddiqui MT: LEF-1: diagnostic utility in distinguishing basaloid neoplasms of the salivary gland. Diagn Cytopathol 2017; 45: 1078–1083.
Vicandi B, Jiménez-Heffernan JA, López- Ferrer P, González-Peramato P, Patrón M, Viguer JM: Fine needle aspiration cytology of basal cell adenoma of the salivary gland: a cytohistological correlation study of 35 cases. Cytopathology 2012; 23: 315–319.
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