Objective: Amyloidomas are tumor-like deposits of amyloid. Amyloidoma of the gastrointestinal tract is rare. To the best of our knowledge, this is the first instance of diagnosis of an amyloidoma in the gastrointestinal tract by fine needle aspiration (FNA). Study Design: We report a case of a 64-year-old male with a history of ulcerative colitis and primary sclerosing cholangitis who was incidentally found to have a mass in the stomach wall. Results: Initially thought to be gastrointestinal stromal tumor, FNA demonstrated the lesion to be amyloidoma with a prominent giant cell reaction. This was further confirmed by mass spectrometry. This is the only case report of diagnosis of a gastric amyloidoma by FNA. Conclusion: The presence of a florid giant cell reaction in the absence of ulceration or an inflammatory or neoplastic lesion should alert the pathologist to the possibility of an amyloidoma. This is the only case report of diagnosis of a gastric amyloidoma by FNA.

1.
Dastur KJ, Ward JF: Amyloidoma of the stomach. Gastrointest Radiol 1980; 5: 17–20.
2.
Oyasiji T, Yood S: Jejunal amyloidoma – a rare cause of gastrointestinal bleeding. Cases Journal 2009; 2: 9100.
3.
Saindane A, Losada M, Macari M: Focal amyloidoma of the small bowel mimicking adenocarcinoma on CT. AJR 2005; 185: 1187–1189.
4.
Garg M, Kaur G, Mahajan NC, Goyal S: Primary localized amyloidoma of abdominal wall presenting as abscess: rare case. Oncol Gastroenterol Hepatol Rep 2015; 4: 1.
5.
Grunes D, Rapkiewicz A, Simsir A: Amyloidoma secondary to insulin injection: cytologic diagnosis and pitfalls. Cytol J 2015; 12: 15.
6.
Verhoeven F, Prati C, Wendling D: Amyloidoma, an unusual cause of fracture. Case Rep Rheumatol 2014; 2014: 424056.
7.
Cloft HJ, Quint DJ, Markert JM, Iannettoni MD, Papadopoulos SM: Primary osseous amyloidoma causing spinal cord compression. AJNR 1995; 16: 1152–1154.
8.
Kapoor R, Bhattacharyya T, Bahl A, Agarwal R, Bal A, Gulati A: Primary amyloidoma of lung treated with radiation: a rare case report. Lung India 2014; 31: 404–406.
9.
Manucha V, Arora VK, Singh N, Bhatia A: Aspiration cytology diagnosis of a primary amyloid tumor of thoracic vertebra: a case report. Diagn Cytopathol 2003; 29: 160–162.
10.
Zheng L, Yang X, Pan H, Nie X, He J, Lv Q, Tong Q: Gastric carcinoma with osteoclast-like giant cells: a case report and review of the literature. J Zhejiang Univ Sci B 2009; 10: 237–241.
11.
Poulios C, Koletsa T, Goulas A, Karayannopoulou G, Vrettou E, Kostopoulos L: Gastric carcinoma with osteoclast-like giant cells coexisting with gastrointestinal spindle cell tumor. Case Rep Pathol 2013; 2013: 240758.
12.
Dhakal M, Dhakal OP, Sherpa M, Gupta A, Bhandari D: Large gastric ulcer: result of foreign body-induced giant cell reaction. J Digest Endosc 2013; 4: 78–81.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.