Background: Intranodal palisaded myofibroblastoma (IPM) is a rare, lymph node mesenchymal neoplasm; the cytologic features are limited in the literature. Case: The patient was a 51-year-old female who had a firm, palpable mass in the right inguinal region. Fine-needle aspiration (FNA) was performed. The smears revealed large, 3-dimensional clusters of cohesive spindle cells, densely surrounding a central, orange-colored, acellular matrix core. These cells had a single, elongated nucleus and an inconspicuous nucleolus. Also seen were spindle cells in short fascicles with dense cytoplasm. The spindle cells were loosely arranged in a single-cell pattern. In addition to the spindle cells and matrix, hemosiderin granules were scattered in the background. A few lymphocytes were identified. Conclusion: A diagnosis of IPM should be considered when FNA smears of lymph node show bland spindle cells in various patterns including single cells, short fascicles, large cohesive clusters with core amianthoid fibers and background hemosiderin granules.

Alguacil-Garcia A: Intranodal myofibroblastoma in a submandibular lymph node. A case report. Am J Clin Pathol 1992;97:69-72.
Dei Tos AP, Della Libera D, Bittesini L: Aspiration biopsy cytology of intranodal myofibroblastoma: case report with immunocytochemical analysis. Diagn Cytopathol 1995;13:134-138.
Martinez-Onsurbe P, Jimenez-Heffernan JA, Guadalix-Hidalgo G: Fine needle aspiration cytology of intranodal myofibroblastoma. A case report. Acta Cytol 2002;46:1143-1147.
Weiss SW, Gnepp DR, Bratthauer GL: Palisaded myofibroblastoma. A benign mesenchymal tumor of lymph node. Am J Surg Pathol 1989;13:341-346.
Suster S, Rosai J: Intranodal hemorrhagic spindle-cell tumor with ‘amianthoid' fibers. Report of six cases of a distinctive mesenchymal neoplasm of the inguinal region that simulates Kaposi's sarcoma. Am J Surg Pathol 1989;13:347-357.
Eyden BP, et al: Intranodal myofibroblastoma: report of a case. Ultrastruct Pathol 1996;20:79-88.
Laskin WB, et al: Intranodal palisaded myofibroblastoma: another mesenchymal neoplasm with CTNNB1 (beta-catenin gene) mutations: clinicopathologic, immunohistochemical, and molecular genetic study of 18 cases. Am J Surg Pathol 2015;39:197-205.
Nguyen T, Eltorky MA: Intranodal palisaded myofibroblastoma. Arch Pathol Lab Med 2007;131:306-310.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.