Objective: The aim of this study was to evaluate the diagnostic accuracy of fine needle aspiration (FNA) cytology of benign salivary gland tumors with myoepithelial cell participation, namely, pleomorphic adenoma, basal cell adenoma and myoepithelioma, at a single institution over a period of 10 years. Study Design: This study was based on 575 cytologic and matching histological samples (534 pleomorphic adenomas, 26 basal cell adenomas and 15 myoepitheliomas). Results: In most cases (393/534) of pleomorphic adenoma, a precise diagnosis was given. However, only 2 cases of basal cell adenoma and 1 case of myoepithelioma were diagnosed definitively. Descriptive diagnosis, instead of a definite diagnosis, was rendered in 16.9% of pleomorphic adenomas, 53.8% of basal cell adenomas and 40.0% of myoepitheliomas. Among all cases, the possibility of malignancy was raised in 5.2% of pleomorphic adenomas, 15.4% of basal cell adenomas and 20.0% of myoepitheliomas with a variable degree of suspicion. Conclusion: In some cases, the distinction between these three neoplasms remains difficult in that all exhibit some degree of myoepithelial participation. However, FNA showed a high diagnostic accuracy in diagnosing benign salivary tumors with myoepithelial differentiation, and triage into this category provides sufficient information for clinicians to make treatment decisions.

1.
Viguer JM, Vicandi B, Jimenez-Heffernan JA, Lopez-Ferrer P, Limeres MA: Fine needle aspiration cytology of pleomorphic adenoma. An analysis of 212 cases. Acta Cytol 1997;41:786-794.
2.
Kechagias N, Ntomouchtsis A, Valeri R, Patrikidou A, Kitikidou K, Xirou P, Destouni C, Vahtsevanos K, Antoniades K: Fine-needle aspiration cytology of salivary gland tumours: a 10-year retrospective analysis. Oral Maxillofac Surg 2012;16:35-40.
3.
Riley N, Allison R, Stevenson S: Fine-needle aspiration cytology in parotid masses: our experience in Canterbury, New Zealand. ANZ J Surg 2005;75:144-146.
4.
Stewart CJ, MacKenzie K, McGarry GW, Mowat A: Fine-needle aspiration cytology of salivary gland: a review of 341 cases. Diagn Cytopathol 2000;22:139-146.
5.
Eveson JW, Kusafuka K, Stenman G, Nagao T, et al: Pleomorphic adenoma; in Barnes L, Eveson JW, Reichart P, Sidransky D: World Health Organization Classification of Tumors. Pathology and Genetics of Head and Neck Tumours. Lyon, IRAC, 2004, p 254.
6.
Mukunyadzi P: Review of fine-needle aspiration cytology of salivary gland neoplasms, with emphasis on differential diagnosis. Am J Clin Pathol 2002;118(suppl):S100-S115.
7.
Zarbo RJ, Prasad AR, Regezi JA, Gown AM, Savera AT: Salivary gland basal cell and canalicular adenomas: immunohistochemical demonstration of myoepithelial cell participation and morphogenetic considerations. Arch Pathol Lab Med 2000;124:401-405.
8.
Siddaraju N, Badhe BA, Goneppanavar M, Mishra MM: Preoperative fine needle aspiration cytologic diagnosis of spindle cell myoepithelioma of the parotid gland: a case report. Acta Cytol 2008;52:495-499.
9.
Vicandi B, Jimenez-Heffernan JA, Lopez-Ferrer P, Gonzalez-Peramato P, Patron M, Viguer JM: Fine needle aspiration cytology of basal cell adenoma of the salivary gland: a cytohistological correlation study of 35 cases. Cytopathology 2012;23:315-319.
10.
Khademi B, Kazemi T, Bayat A, Bahranifard H, Daneshbod Y, Mohammadianpanah M: Salivary gland myoepithelial neoplasms: a clinical and cytopathologic study of 15 cases and review of the literature. Acta Cytol 2010;54:1111-1117.
11.
Hara H, Oyama T, Saku T: Fine needle aspiration cytology of basal cell adenoma of the salivary gland. Acta Cytol 2007;51:685-691.
12.
Kawahara A, Harada H, Akiba J, Yokoyama T, Kage M: Fine-needle aspiration cytology of basal cell adenoma of the parotid gland: characteristic cytological features and diagnostic pitfalls. Diagn Cytopathol 2007;35:85-90.
13.
Hruban RH, Erozan YS, Zinreich SJ, Kashima HK: Fine-needle aspiration cytology of monomorphic adenomas. Am J Clin Pathol 1988; 90:46-51.
14.
Hood IC, Qizilbash AH, Salama SS, Alexopoulou I: Basal-cell adenoma of parotid. Difficulty of differentiation from adenoid cystic carcinoma on aspiration biopsy. Acta Cytol 1983;27:515-520.
15.
Cuadra Zelaya F, Quezada Rivera D, Tapia Vazquez JL, Paez Valencia C, Gaitan Cepeda LA: Plasmacytoid myoepithelioma of the palate. Report of one case and review of the literature. Med Oral Patol Oral Cir Bucal 2007;12:E552-E555.
16.
Kumar PV, Sobhani SA, Monabati A, Hashemi SB, Eghtadari F, Hamidi SA: Myoepithelioma of the salivary glands. Fine needle aspiration biopsy findings. Acta Cytol 2004;48:302-308.
17.
Kim NR CH, Ha SY: Cytology of plasmacytoid type myoepithelioma: report of two cases. Korean J Pathol 2009;43:489-493.
18.
Faquin WC PC: Salivary Gland Cytopathology. New York, Springer, 2008, pp 97-103, 118-120.
19.
Pusztaszeri M, Braunschweig R, Mihaescu A: Pleomorphic adenoma with predominant plasmocytoid myoepithelial cells: a diagnostic pitfall in aspiration cytology. Case report and review of the literature. Diagn Cytopathol 2009;37:56-60.
20.
Handa U, Dhingra N, Chopra R, Mohan H: Pleomorphic adenoma: cytologic variations and potential diagnostic pitfalls. Diagn Cytopathol 2009;37:11-15.
21.
DeMay RM: The Art and Science of Cytopathology. Chicago, American Society for Clinical Pathology Press, 2012, pp 802-803.
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