Background: Central neurocytomas (CNs) are infrequent intraventricular tumors with features of neuronal differentiation that affect young adults and have an excellent prognosis after total resection. The main differential intraoperative diagnoses are oligodendrogliomas, ependymomas and non-Hodgkin's lymphomas; therefore, an accurate and precise intraoperative diagnosis is essential, making the cytologic features the hallmark for cytopathologists, surgical pathologists and neurosurgeons alike. Seven previous reports have described 18 cases of CNs and have addressed the cytodiagnostic criteria during intraoperative assessment in the English medical literature. Cases: Three patients (23 years old/male, 29 years old/female and 28 years old/male) were evaluated during intraoperative assessment as CNs. They showed intraventricular tumors that measured 6.5, 3.5 and 6.6 cm, respectively. The cytologic features common in these cases were: (1) monotonous or isomorphic round cells, (2) small nuclei with stippled or granular chromatin, and (3) acellular fibrillary areas or neuropil (islands). Other cytologic features often encountered were: rosette-like structures, micronucleoli, perinuclear haloes, well-formed capillary-sized vessels and calcifications. Conclusion: Differential diagnosis of CNs can be a diagnostic challenge. The integration of radiologic imaging and touch preparations taking into account specific cytologic features and frozen sections is necessary for an optimal intraoperative assessment.

1.
Hassoun J, Gambarelli D, Grisoli F, Pellet W, Salamon G, Pelisier JF, Toga M: Central neurocytoma: an electron microscopic studies of two cases. Acta Neuropathol (Berl) 1982;56:151-156.
2.
Louis DN, Ohgaki H, Weistler OD, Cavanee WK: WHO Classification of Tumors of the Central Nervous System. Lyon, International Agency for Research on Cancer, 2007, pp 54-109.
3.
Hassoun J, Soylemezoglu F, Gambarelli D, Figarella-Branger D, von Ammon K, Kleihues P: Central neurocytoma: a synopsis of clinical and histological features. Brain Pathol 1993;3:297-306.
4.
Kim DG, Chi JG, Park SH, Chang KH, Lee SH, Jung HW, Kim HJ, Cho BK, Choi KS, Han DH: Intraventricular neurocytoma: clinicopathological analysis of seven cases. J Neurosurg 1992;76:759-765.
5.
Figarella-Branger D, Pellissier JF, Daumas-Duponrt C, Delisle MB, Pasquier B, Parent M, Gabarrelli D, Rougon G, Hassaound J: Central neurocytoma: critical evaluation of small-cell neuronal tumor. Am J Surg Pathol 1992;16:97-109.
6.
Barbosa MD, Balsitis M, Jaspan T, Lowe J: Intraventricular neurocytoma: a clinical and pathological study of three cases and review of the literature. Neurosurgery 1990;26:1045-1054.
7.
Johnson ES, Nguyen-Ho P, Nguyen G-K: Cytology of central neurocytoma in intraoperative crush preparations. A case report. Acta Cytol 1994;38:764-766.
8.
Ng H-K: Cytologic features of central neurocytomas of the brain: a report of three cases. Acta Cytol 1999;43:252-256.
9.
Sugita Y, Tokunaga O, Morimatsu M, Abe H: Cytodiagnosis of central neurocytoma in intraoperative preparations. Acta Cytol 2004;48:-194-208.
10.
Kobayashi TK, Bamba M, Ueda M, Nishino T, Muramatsu M, Hino A, Shima A, Echigo T, Oka H: Cytological diagnosis of central neurocytoma in squash preparations: a report of two cases. Acta Cytol 2010;54:209-213.
11.
Klysik M, Gavito J, Boman D, Miranda RN, Hanbali F, De Las Casas LE: Intraoperative imprint cytology of central neurocytoma: the great oligodendroglioma mimicker. Diagn Cytopathol 2010;38:202-207.
12.
Jaiswal S, Vij M, Jaiswal AK, Behari S: Squash cytomorphology of central neurocytoma: a study of five cases. Diag Cytopathol 2010;40:678-683.
13.
Yang GCH, Hoda SA: Combined use of the ‘scratch and smear' sampling technique and ultrafast Papanicolaou stain for intraoperative cytology. Acta Cytol 1997;41:1513-1518.
14.
Kobayashi TK, Bamba M, Oka H, Hino A, Fujimoto M, Katsumori T, Moritani S, Kushima R, Kaneko C: Granular cell tumor of the neurohypophysis on cytological squash preparations. Cytopathology 2006;17:153-161.
15.
Iqbal M, Shah A, Wani MA, Kirmani A, Ramzan A: Cytopathology of central nervous system. 1. Utility of crush smear cytology in intraoperative diagnosis of central nervous system lesions. Acta Cytol 2006;50:608-616.
16.
De las Casas, Gokden M, Mukunyadzi P, White P, Baker SJ, Hermonat PL, You H, Korourian S, Malak SF, Miranda RN: A morphologic and statistical comparative study of small-cell carcinoma and non-Hodking's lymphoma in fine needle aspiration biopsy material form lymph nodes. Diag Cytopathol 2004;31:229-234.
17.
Altermatt HJ, Scheithauer BW: Cytomorphology of subependymal giant cell astrocytoma. Acta Cytol 1992;36:171-175.
18.
Teo JG-C, NG H-K: Cytodiagnosis of pilocytic astrocytoma in smear preparations. Acta Cytol 1998;42:673-678.
19.
Sharma MC, Deb P, Sharma S, Sarkar C: Neurocytoma. A comprehensive review. Neurosurg Rev 2006;92:270-285.
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