Cytology features of childhood jaw tumors are infrequently reported in the literature. Fine-needle aspiration cytology (FNAC) has been used with good results in the differential diagnosis of bone lesions, being an excellent tool for the diagnosis of metastases and in the frontline approach to primary lesions. We report 3 cases of young children aged 3 years (case 1), 5 months (case 2), and 15 years (case 3) with jaw tumors diagnosed by FNAC. In the first two cases the diagnosis was prognoma, and in the third case cementifying fibroma. Despite the clinical and imaging similarity of the 3 cases – large maxillary/mandibular tumors – their characteristic cytological features allowed a confident diagnosis, excluding other differential alternatives. In both case 1 and case 2 a dual cell population of neuroepithelial and melanocytic cells was identified, consistent with a melanotic neuroectodermal tumor. In case 3 the presence of a bland spindle cell population as well as of several nodular dense eosinophilic, osteoid-like (cement) matrices, indicated a cementifying fibroma. All cases were resected and confirmed by histological examination. A review of the literature, including differential diagnosis, addresses the utility of FNAC in childhood jaw tumors.

Keywords:
Cytology, Fine-needle aspiration, Childhood, Jaw, Melanotic neuroectodermal tumor, Prognoma, Cementifying fibroma
1.
Dehner LP: Tumours of the mandible and maxilla in children. 1. Clinicopathologic study of 46 histologically benign lesions. Cancer 1973;31:364–384.
2.
Dehner LP: Tumours of the mandible and maxilla in children. 2. A study of 14 primary and secondary malignant tumors. Cancer 1973;32:112–120.
3.
Melkert PW: Fine needle aspiration cytology of bone lesions: analysis of a three-year experience in rural Africa. Acta Cytol 1990;34:677–680.
4.
Inwards CY: Low-grade central osteosarcoma versus fibrous dysplasia. Pathol Case Rev 2001;6:22–27.
5.
Baghaie F, Motahhary P: Osteosarcoma of the jaws: a retrospective study. Acta Med Iran 2003;41:113–121.
6.
Gupta N, Gupta R, Bakshi J, Rajwanshi A: Fine needle aspiration cytology in a case of fibrous dysplasia of jaw. Diagn Cytopathol 2009;37:920–922.
7.
Gupta N, Kaur J, Srinivasan R, Das A, Mohindra S, Rajwanshi A, Raje Nijhawan R: Fine needle aspiration cytology in lesions of the nose, nasal cavity and paranasal sinuses. Acta Cytol 2011;55:135–141.
8.
Lee SE, Lee HE, Park H, Sung JY, Lee HW, Kang SY, Seo S, Kim BH, Lee H, Seo AN, Ahn G, Choi YL: The diagnostic utility of the GNAS mutation in patients with fibrous dysplasia: meta-analysis of 168 sporadic cases. Hum Pathol 2012;1234–1242.
© 2012 S. Karger AG, Basel
2012
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