Objective: We identified unique vegetable cell-like structures in urinary diversion specimens. This study aimed to describe their cytomorphology and prevalence and to investigate the possible origin of these contaminants. Study Design: A 10-year retrospective review of urinary diversion urine specimens with reported vegetable cell-like structures was performed. Data regarding patient demographics, previous history and specimen cytomorphology were recorded. To determine their prevalence, 100 urinary diversion cases were screened. Stoma materials were evaluated as possible contaminant sources. Results: A total of 11 urine cases from 7 patients (mean age 64 years; male/female ratio 2.5:1; all with ileal conduits) were identified with contaminating vegetable cell-like structures. These thick-walled cells contained dense, smudged cores and pericentral clearing. In 27% of cases, the specimens were less than optimal or unsatisfactory for evaluation due to low cellularity and associated lubricant material. No contaminating vegetable cell-like structures were found in the 100 screened cases. Stoma care products tested did not yield any morphologically similar structures. Conclusion: Vegetable cell-like structures may rarely be identified as a contaminant in urinary diversion specimens, possibly from stoma care material. Associated lubricant may affect specimen adequacy. These vegetable cell-like structures must be distinguished from true pathologic structures such as koilocytes or parasitic ova.

Malmgren RA, Soloway MS, Chu EW, Del Vecchio PR, Ketcham AS: Cytology of ileal conduit urine. Acta Cytol 1971;15:506–509.
Wolinska WH, Melamed MR: Urinary conduit cytology. Cancer 1973;32:1000–1006.
Morris EJ, Bracken RB, Hopfer RL, Mills K, Rodriguez DB: Urinary findings in 20 asymptomatic patients with an ileal conduit. J Enterostomal Ther 1982;9:24–27.
Parekh DJ, Donat SM: Urinary diversion: options, patient selection, and outcomes. Semin Oncol 2007;34:98–109.
Korhonen AM, Issakainen J, Ekfors T, Talve L, Rantio-Lehtimaki A: Summer spores of birch rust fungus in Papanicolaou smears from healthy mass screening participants. Acta Cytol 2001;45:679–682.
Martinez-Giron R, Gonzalez-Lopez JR, Escobar-Stein J, Jou-Munoz C, Garcia-Miralles M, Ribas-Barcelo A: Freshwater microorganisms and other arthropods in Papanicolaou smears. Diagn Cytopathol 2005;32:222–225.
Martinez-Giron R, Jodra-Fernandez O, Tormo-Molina R, Esteban JG, Ribas-Barcelo A: Uncommon structures simulating helminth eggs in sputum. Acta Cytol 2005;49:578–580.
Martinez-Giron R, Menendez-Rodriguez P, Tamargo-Pelaez ML, Torre-Bayon C, Lopez-Cabanilles D, Ribas-Barcelo A: Crystalloid structures in a cervicovaginal smear: an observation different from the gynaecological perspective. Diagn Cytopathol 2007;35:738–739.
Martinez-Giron R, Ribas-Barcelo A: Algae in cytologic smears. Acta Cytol 2001;45:936–940.
Martinez-Giron R, Ribas-Barcelo A, Garcia-Miralles MT, et al: Airborne fungal spores, pollen grains, and vegetable cells in routine Papanicolaou smears. Diagn Cytopathol 2004;30:381–385.
Martinez-Giron R, Ribas-Barcelo A, Garcia-Miralles T, et al: Diatoms and rotifers in cytological smears. Cytopathology 2003;14:70–72.
Martinez-Giron R, Salona-Bordas MI, Ribas-Barcelo A: Striking aquatic life structure found in a sputum smear. Diagn Cytopathol 2008;36:38–39.
Weaver KM, Novak PM, Naylor B: Vegetable cell contaminants in cytologic specimens: their resemblance to cells associated with various normal and pathologic states. Acta Cytol 1981;25:210–214.
Rivasi F, Tosi G, Ruozi B, Curatola C: Vegetable cells in Papanicolaou-stained cervical smears. Diagn Cytopathol 2006;34:45–49.
Holton T, Smith D, Terry M, Madgwick A, Levine T: The effect of lubricant contamination on ThinPrep (Cytyc) cervical cytology liquid-based preparations. Cytopathology 2008;19:236–243.
Feit TD, Mowry DA: Interference potential of personal lubricants and vaginal medications on ThinPrep Pap tests. J Am Board Fam Med 2011;24:181–186.
AbdullGaffar B, Kamal MO, Khalid M, Samuel R, AlGhufli R: Lubricant, mucus, and other contaminant materials as a potential source of interpretation errors in ThinPrep cervical cytology. J Low Genit Tract Dis 2010;14:22–28.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.