Objective: To assess the performance of fine needle aspiration cytology (FNAC) in preoperative diagnosis of parakeratotic odontogenic keratocyst. Study Design: Twenty-three cases of odontogenic keratocyst which were evaluated with FNAC prior to enucleation were included in the study. Aspiration smears were stained with Papanicolaou and hematoxylin-eosin stain. Results obtained from FNAC were compared with histopathologic data obtained from the excisional biopsies. Results: Keratotic cell clusters with or without inflammation were identified in all the cytologic smears. No dysplastic changes were seen. The evaluation of the excisional biopsies revealed cystic epithelium which is characterized by palisaded basal cells, a corrugated surface with a lumen containing keratin debris. Two of the cases which revealed satellite cysts were not associated with Gorlin-Goltz syndrome due to the absence of other findings. Conclusion: Parakeratotic odontogenic keratocyst can be substantially diagnosed preoperatively utilizing FNAC with a careful evaluation.

1.
Philipsen HP: Om keratocyster (kolesteatom) i kaekberne. Tandlaegebladet 1956;60:963–980.
2.
Brannon RB: The odontogenic keratocyst: a clinopathologic study of 312 cases. Part 1. Clinical features. Oral Surg Oral Med Oral Pathol 1976;42:52–72.
3.
Blanas N, Freund B, Schwartz M, Furst IM: Systematic review of the tratment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:553–558.
4.
Farish SE, Di Leo CT: A case report. Underdiagnosis of an odontogenic keratocyst: common cyst can be controversial lesion. J Am Dent Assoc 1994;125:738–741.
5.
Payne TF: An analysis of the clinical and histopathologic parameters of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol 1972;33:538–546.
6.
Manfredi M, Vesconi P, Bonanini M, Porter S: Nevoid basal cell carsinoma syndrome: a review of the literature. Int J Oral Maxillofac Surg 2004;33:117–124.
7.
Philipsen HP: Keratocystic odontogenic tumour; in Barnes L, Eveson JW, Reichart P, Sidransky D (eds): World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours.. Lyon, IARC Press, 2005, pp 306–307.
8.
August M, Faquin WC, Troulis M, Kaban LB: Differentiation of odontogenic keratocysts from nonkeratinizing cysts by use of fine-needle aspiration biopsy and cytokeratin-10 staining. J Oral Maxillofac Surg 2000;58:935–940.
9.
Kramer IR, Toller PA: The use of exfoliative cytology and protein estimations in preoperative diagnosis of odontogenic keratocysts. Int J Oral Surg 1973;2:143–151.
10.
Vargas PA, Cruz Perez DE, Mata GM, Almeida OP, Jones AV, Gerhard R: Fine needle aspiration cytology as an additional tool in the diagnosis of odontogenic keratocyst. Cytopathology 2007;18:361–366.
11.
Browne RM: The odontogenic keratocyst: histologic features and their correlation with clinical behaviour. Br Dent J 1971;131:249–259.
12.
Günhan O, Doğan N, Celasun B, Sengün O, Onder T, Finci R: Fine needle aspiration of oral cavity and jaw bone lesions. Acta Cytol 1993;37:135–141.
13.
Uçok O, Doğan N, Uçok C, Günhan O: Role of fine needle aspiration cytology in the preoperative presumptive diagnosis of ameloblastoma. Acta Cytol 2005;49:38–42.
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