... streptozotocin-diabetic rats, 2.5 months after administration of the drug, an early time point when specific diabetic glomerular changes were still minimal. Ten age-matched Sprague-Dawley rats were assigned to control and diabetic groups. Compared to the controls, the diabetic rats had a significantly lower body...

...K.R. Copeland; R.W. Yatscoff; A.E. Mehta; J.A. Thliveris The effect of chronic hyperglycemia on the relationship of nonenzymatic glycation and capillary basement membrane thickness in muscle was studied in streptozotocin-induced diabetic rats early in the course of diabetes mellitus. Diabetic...

...Erminio Giavini; Mariangela Prati The eye development of rat fetuses and pups from normal and streptozotocin-diabetic mothers was studied histologically in order to verify the morphopathogenesis of congenital cataract. The first signs of lens alterations were observed in 17-day-old fetuses from...

...S. Bhimji; D.V. Godin; J.H. McNeill The ultrastructural changes in the left ventricles of rabbits with alloxan (100 mg/kg i.v.)-induced diabetes were examined. Injection of alloxan resulted in a diabetic state characterized by increased hemoglobin glycosylation, blood and urine glucose...

...I. Zusman; P. Yaffe; A. Ornoy The ultrastructure of the visceral yolk sac endoderm of in vivo developing 9- to 13-day-old embryos from 2 diabetic rat models (streptozotocin diabetes and Cohen – genetically determined – diabetes) and from non-diabetic rats fed high sucrose diets have been studied...

...Susan Marion; Edward C. Carlson Renal changes similar to those considered diagnostic for diabetes in humans are infrequently observed in spontaneous noninsulin-dependent (NID) diabetic monkeys. In the current study, renal cortical tissue blocks are rendered acellular to demonstrate glomerular...

... of /?-cells only, the α-cells remained almost normal. This damage suggests that the β -cells of this frog are functionally like those of mammals and other vertebrates, and secrete insulin. A single dose of glucose was found incapable of producing permanent diabetes, and β -cells damage was repairable at later...