In studying epithelio-stromal interactions in the neonatal hamster lung, basal centrioles, basal cilia and open-ring centrioles attracted our attention. The same structures are also found in bronchiolar epithelium of a 3-week-old fawn-hooded rat, indicating that they are not specific phenomena of hamster lung. Although cells with basal centrioles are not common, they are more readily observed in a sample of bronchioles at the second postnatal week as compared to the fourth neonatal day. The centrioles may often possess two satellites and function as microtubule organizing centers (MTOC). Open-ring centrioles are mature structures and also serve as MTOC. Apparently, triplets may de novo be added to and/or degraded from an open-ring centriole. The basal cilia and the cilia in the ciliated vacuoles/cysts, have a normal axonemal structure and may have a common origin from the basal centrioles. It is, however, unclear whether or not they are primary-like cilia. In addition, presence of the multiple basal MTOC and some morphologic features point to a high microtubule-associated vesicular transport activity and probably indicate an elevated interaction with the interstitium; thus, the cells have a different polarization then normal ciliated cells.

Keywords:
Epithelio-stromal interaction, Lung, Centriole, Cilium, Microtubule, Hamster, Rat
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© 1995 S. Karger AG, Basel
1995
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