Small electrolytic lesions were placed on the head of the caudate nucleus of kittens between 8 and 21 days postnatally and in adult cats. Coronal sections of the whole brain were studied under the light microscope with the Fink and Heimer staining method. Degenerating axon terminals could be recognized after a survival period of 30 h for kittens and 8 days for adults, as dark spots and broken fibers. The results indicate extensive degenerative lesions at both diencephalic and brain stem levels. In general the degenerative lesions were denser in kittens when compared with adult animals. The results of this study suggest that the caudate nucleus of immature animals could be more sensitive to the lesions occurring during the time of early synaptogenesis. Moreover, the caudate nucleus could be an important point of convergence of descending pathways exerting a diffuse modulatory action upon several brain structures related to movement.

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