A comparative study of the enzymes Δ5-3β-HSD, cytochrome oxidase and peroxidase has been made in the ovaries and uterus of mammals (mouse, guinea pig, cat and dog) during various reproductive phases. The granulosa cells of developing follicles, hypertrophied interstitial cells of thecal origin and the luteal cells show intense Δ5-3β-HSD and cytochrome oxidase activity. Peroxidases are found to be present in the corpus luteum and the epithelial cords of thecal origin. Δ5-3β-HSDand cytochrome oxidase activity is localized to the endometrium and myometrium of mature and pregnant uterus of mouse and guinea pig, while peroxidase is seen only in the decidua and endometrial glands of pregnant animals. The significance of these enzymes is discussed in relation to the cellular basis of luteinization and steroid hormone synthesis.

Keywords:
Peroxidase, Cytochrorae oxidase, Δ5-3β-HSD, Ovary, Uterus, Reproductive cycle
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© 1978 S. Karger AG, Basel
1978
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