Neural crest cells in the pre- and postnatal development of mice showed a specific sensitivity to mitomycin C. In mice injected with mitomycin C 24–48 h after birth and surviving up to the 9th day, a free or attached denticle in the pulp and a fibroma or excessive cell proliferation in the dental follicle or the periodontal ligament were seen; further, a dentinoma developed.

Keywords:
Postnatal tooth development, Mice, Neural crest cells, Mitomycin C
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© 1978 S. Karger AG, Basel
1978
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